TAM and TIM receptors mRNA expression in Zika virus infected placentas

Author(s):Show less -

Nobrega, Guilherme M. ^{[1, 2]} ; Samogim, Ana Paula ^[2] ; Parise, Pierina L. ^[2] ; Venceslau, Emanuella M. ^[1] ; Guida, Jose Paulo S. ^[1] ; Japecanga, Rodolfo R. ^[1] ; Amorim, Mariene R. ^[2] ; Toledo-Teixeira, Daniel A. ^[2] ; Forato, Julia ^[2] ; Consonni, Silvio R. ^[3] ; Costa, Maria Laura ^[1] ; Proenca-Modena, Jose Luiz ^{[2, 4]} ; Network, Zika-Unicamp

Affiliation

^[1] Univ Campinas UNICAMP, Sch Med Sci, Dept Obstet & Gynecol, Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Campinas, SP - Brazil

^[3] Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil

^[4] Univ Campinas UNICAMP, Expt Med Res Cluster EMRC, Campinas, SP - Brazil

• Document type: Journal article
• Source: Placenta; v. 101, p. 204-207, NOV 2020.
• Web of Science Citations: 0

Abstract

To investigate the role of TYRO3, AXL and TIM1 receptors in the Zika virus (ZIKV) cycle, we determined their mRNA expression in different placental sites of ZIKV infected tissue during pregnancy. Unexpectedly, the ZIKV infection was not related with mRNA upregulation of these receptors or changes in expression of type I and III interferons in different placental sites. Instead, a decrease of TYRO3 mRNA expression was observed in positive sites of ZIKV positive placentas in comparison to negative sites. The basis of this downregulation can help to understand how ZIKV persists in placental tissue during pregnancy. (AU)

• FAPESP's process: 17/26908-0 - The role of IRF-5 in Oropouche virus pathogenesis and neurovirulence
• Grantee: Pierina Lorencini Parise
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 17/22062-9 - Arbovirus detection and characterization in Campinas
• Grantee: Julia Forato
• Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
• FAPESP's process: 17/02402-0 - The role of adaptive immune response in neuroinvasion by Oropouche and Zika virus
• Grantee: Daniel Augusto de Toledo Teixeira
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 19/18720-6 - Characterization of placental Virome and immune transcriptome of pregnant women with Zika Virus infection and high-risk pregnancies
• Grantee: Guilherme de Moraes Nobrega
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 16/00194-8 - Pathogenesis and neurovirulence of emerging viruses in Brazil
• Grantee: José Luiz Proença Módena
• Support Opportunities: Research Grants - Young Investigators Grants