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The role of adaptive immune response in neuroinvasion by Oropouche and Zika virus

Grant number: 17/02402-0
Support type:Scholarships in Brazil - Master
Effective date (Start): June 01, 2017
Effective date (End): February 28, 2019
Field of knowledge:Biological Sciences - Microbiology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:José Luiz Proença Módena
Grantee:Daniel Augusto de Toledo Teixeira
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:16/00194-8 - Pathogenesis and neurovirulence of emerging viruses in Brazil, AP.JP


Emerging viruses, mainly those transmitted by arthropods widely spread in urban areas, are a great concern for public health worldwide. Zika virus (ZIKV) is an emerging virus in Brazil often associated with fever-rash illness and some serious complications, such as a Guillain-Barré like syndrome and congenital malformations, including microcephaly. Oropouche virus (OROV) is another emerging virus with epidemic potential for Brazilian population. This agent is associated with febrile illness and meningoencephalitis in the Amazon. However, the pathogenetic aspects associated with neuropathogenesis of both viruses are not completely understood. Thus, the aim of this study is to evaluate the role of B and T cells during neuropathogenesis of ZIKV and OROV. Therefore, we will determine the morbidity and mortality of mice without mature B and/or T cells after OROV and ZIKV infection. We will also characterize the viral replication, tissue histopathology, blood chemistry and cytokine production in the peripheral blood after viral infection. (AU)