The role of adaptive immune response in neuroinvasion by Oropouche and Zika virus

• Grant number: 17/02402-0
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): June 01, 2017
• Effective date (End): February 28, 2019
• Field of knowledge: Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: José Luiz Proença Módena
• Grantee: Daniel Augusto de Toledo Teixeira
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 16/00194-8 - Pathogenesis and neurovirulence of emerging viruses in Brazil, AP.JP

Abstract

Emerging viruses, mainly those transmitted by arthropods widely spread in urban areas, are a great concern for public health worldwide. Zika virus (ZIKV) is an emerging virus in Brazil often associated with fever-rash illness and some serious complications, such as a Guillain-Barré like syndrome and congenital malformations, including microcephaly. Oropouche virus (OROV) is another emerging virus with epidemic potential for Brazilian population. This agent is associated with febrile illness and meningoencephalitis in the Amazon. However, the pathogenetic aspects associated with neuropathogenesis of both viruses are not completely understood. Thus, the aim of this study is to evaluate the role of B and T cells during neuropathogenesis of ZIKV and OROV. Therefore, we will determine the morbidity and mortality of mice without mature B and/or T cells after OROV and ZIKV infection. We will also characterize the viral replication, tissue histopathology, blood chemistry and cytokine production in the peripheral blood after viral infection. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NOBREGA, GUILHERME M.; SAMOGIM, ANA PAULA; PARISE, PIERINA L.; VENCESLAU, EMANUELLA M.; GUIDA, JOSE PAULO S.; JAPECANGA, RODOLFO R.; AMORIM, MARIENE R.; TOLEDO-TEIXEIRA, DANIEL A.; FORATO, JULIA; CONSONNI, SILVIO R.; et al. TAM and TIM receptors mRNA expression in Zika virus infected placentas. Placenta, v. 101, p. 204-207, NOV 2020. (17/26908-0, 17/22062-9, 17/02402-0, 19/18720-6, 16/00194-8)

VENCESLAU, EMANUELLA MENESES; SIQUEIRA GUIDA, JOSE PAULO; NOBREGA, GUILHERME DE MORAES; SAMOGIM, ANA PAULA; PARISE, PIERINA LORENCINI; JAPECANGA, RODOLFO ROSA; DE TOLEDO-TEIXEIRA, DANIEL AUGUSTO; FORATO, JULIA; ANTOLINI-TAVARES, ARTHUR; SOUZA, ARETHUSA; et al. Adequate Placental Sampling for the Diagnosis and Characterization of Placental Infection by Zika Virus. FRONTIERS IN MICROBIOLOGY, v. 11, FEB 21 2020. (17/26908-0, 16/00194-8, 17/02402-0)

SILVA-FILHO, JOAO LUIZ; DE OLIVEIRA, LILIAN G.; MONTEIRO, LETICIA; PARISE, PIERINA L.; ZANLUQUI, NAGELA G.; POLONIO, CAROLINA M.; DE FREITAS, CARLA L.; TOLEDO-TEIXEIRA, DANIEL A.; DE SOUZA, WILLIAM M.; BITTENCOURT, NAJARA; et al. Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice. BRAIN BEHAVIOR AND IMMUNITY, v. 97, p. 260-274, OCT 2021. (17/26908-0, 16/00194-8, 20/02159-0, 16/21259-0, 18/13866-0, 16/12855-9, 17/22062-9, 17/26170-0, 17/11828-0, 17/02402-0, 20/02448-2, 18/13645-3, 16/07371-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

TEIXEIRA, Daniel Augusto de Toledo. The role of adaptive immune response in neuroinvasion by Oropouche virus. 2019. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.