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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Strength training protects against prostate injury in alcoholic rats

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Author(s):
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Teixeira, Giovana Rampazzo [1, 2, 3] ; Almeida Chuffa, Luiz Gustavo [4] ; Mendes, Leonardo Oliveira [5] ; Cruz Veras, Allice Santos [1] ; McCabe, James [6] ; Favaro, Wagner Jose [7] ; Felipe Pinheiro, Patricia Fernanda [4] ; Arruda Amorim, Joao Paulo [8] ; Martins, Otavio Augusto [9] ; Mello-Junior, Wilson [4] ; Martinez, Francisco Eduardo [4]
Total Authors: 11
Affiliation:
[1] Sao Paulo State Univ, Postgrad Program Movement Sci, UNESP, Campus Presidente Prudente, Sao Paulo, SP - Brazil
[2] Univ Estadual Paulista, Dept Phys Educ, Sch Technol & Sci, Campus Presidente Prudente, Sao Paulo, SP - Brazil
[3] Sao Paulo State Univ, Postgrad Program Multicentr Physiol Sci, UNESP, Campus Aracatuba, Sao Paulo, SP - Brazil
[4] Sao Paulo State Univ, Inst Biosci, UNESP, Dept Anat, Sao Paulo, SP - Brazil
[5] Univ Western Sao Paulo UNOESTE, Postgrad Program Hlth Sci, Postgrad Program Anim Sci, Presidente Prudente, SP - Brazil
[6] Univ Guelph, Dept Plant Agr, Guelph, ON - Canada
[7] State Univ Campina, Inst Biol, UNICAMP, Dept Struct & Funct Biol, Campinas, SP - Brazil
[8] State Univ Western Parana, Cascavel, Parana - Brazil
[9] Sao Paulo State Univ, Fac Vet Med & Anim Sci, UNESP, Dept Vet Hyg & Publ Hlth, Botucatu, SP - Brazil
Total Affiliations: 9
Document type: Journal article
Source: Journal of Cellular Physiology; v. 236, n. 5 DEC 2020.
Web of Science Citations: 0
Abstract

Alcoholic injury can alter the hormonal signaling pathway and lead to glucose and lipid metabolism disorders. In this study, we investigated whether the strength training could exert protective effects against the alterations caused by ethanol consumption on prostatic metabolism. A UChB, ethanol-preferring rats were used in this study. Strength training was conducted for 3 days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a strength training protocol. The reduced alcohol consumption by strength training was accompanied by increased glucose, serum lipid profile, total protein levels, and reduced hormonal levels. The results of protein expression of prostatic tissues in the ethanol- and strength training-treated groups indicated that ``steroidal hormone receptors,{''} ``fatty acid translocation,{''} and ``cell regulation{''} were significantly different between ethanol- and strength training-treated groups. Taken together, these findings show that strength training effectively ameliorated prostatic injuries in alcoholic rats at least partially by acting on lipids receptors and steroidal hormone receptors pathway, suggesting the strength training as a potential novel therapeutic strategy for treating prostate injuries caused by ethanol. (AU)

FAPESP's process: 13/25927-0 - Effects of ethanol consumption and resistense exercise training on biochemical, hormonal and immunohistochemical parameters of the dorsolateral prostate of rats UChB
Grantee:Verônica Alves de Menezes
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 08/00479-6 - Influence of the resisted physical exercise in the metabolism of the UChB rat ventral prostate (voluntary intake of 10% ethanol)
Grantee:Giovana Rampazzo Teixeira
Support Opportunities: Scholarships in Brazil - Doctorate