Thromboinflammatory mechanisms in sickle cell disease - challenging the hemostatic balance

Author(s)

Conran, Nicola ^[1] ; De Paula, Erich V. ^[1]

Affiliation

^[1] Univ Estadual Campinas, Hematol Ctr, UNICAMP, Cidade Univ, Campinas, SP - Brazil

• Document type: Review article
• Source: Haematologica; v. 105, n. 10, p. 2380-2390, OCT 2020.
• Web of Science Citations: 5

Abstract

Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell properties and shape, as the result of HbS dexoygenation and subsequent polymerization. The pathophysiology of SCD is characterized by chronic inflammatory processes, triggered by hemolytic and vaso-ocdusive events, which lead to the varied complications, organ damage and elevated mortality seen in individuals with the disease. In association with activation of the endothelium and leukocytes, hemostatic alterations and thrombotic events are well-documented in SCD. Here, we discuss the role of inflammatory pathways in modulating coagulation and inducing platelet activation in SCD, due to tissue factor activation, adhesion molecule expression, inflammatory mediator production and the induction of innate immune responses, among other mechanisms. Thromboinflammatory pathways may play a significant role in some of the major complications of SCD, such as stroke, venous thromboembolism and possibly acute chest syndrome, besides exacerbating the chronic inflammation and cellular interactions that trigger vaso-ocdusion, ischemia-reperfusion processes, and eventually organ damage. (AU)

• FAPESP's process: 14/00984-3 - Red blood cell disorders: pathophysiology and new therapeutic approaches
• Grantee: Fernando Ferreira Costa
• Support Opportunities: Research Projects - Thematic Grants