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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biobased Spiroimides from Itaconic Acid and Formamides: Molecular Targets for a Novel Synthetic Application of Renewable Chemicals

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Author(s):
Hornink, Milene Macedo [1] ; Lopes, Alice Uva [1] ; Andrade, Leandro Helgueira [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Chem, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: SYNTHESIS-STUTTGART; v. 53, n. 02, p. 296-308, JAN 19 2021.
Web of Science Citations: 0
Abstract

Spiroimides exhibit a wide range of biological activities, such as anticonvulsant, antiarrhythmic, and antihyperglycemic activities. Herein, a novel synthetic application of renewable chemicals, itaconic acid and formamides, is described. Proper exploitation of the reactivity of itaconic acid and formamide allows for the development of an efficient synthetic approach for the production of several new biobased spiroimides, spiro{[}dihydroquinolin-2-one-succinimides] and spiro{[}indolin-2-one-glutarimides], in excellent overall yields (up to 98%). (AU)

FAPESP's process: 18/07152-4 - Application of vanadium-dependent haloperoxidase in a continuous flow system aiming selective reactions
Grantee:Milene Macedo Hornink
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 19/10762-1 - Development of a synthetic platform using carbamoyl radicals: application of the formamide in the synthesis of heterocyclic compounds
Grantee:Leandro Helgueira de Andrade
Support Opportunities: Regular Research Grants
FAPESP's process: 17/02854-8 - Synthetic applications of carbamoyl radicals via photocatalysis
Grantee:Leandro Helgueira de Andrade
Support Opportunities: Regular Research Grants