Plasma amino acids profile in first-episode psychosis, unaffected siblings and community-based controls

Author(s):Show less -

Loureiro, Camila Marcelino ^{[1, 2, 3]} ; da Roza, Daiane Leite ^[4] ; Corsi-Zuelli, Fabiana ^{[4, 1]} ; Shuhama, Rosana ^{[4, 3]} ; Fachim, Helene Aparecida ^[5] ; Simoes-Ambrosio, Livia Maria Cordeiro ^{[1, 2]} ; Deminice, Rafael ^[6] ; Jordao, Alceu Afonso ^[7] ; Menezes, Paulo Rossi ^{[8, 3]} ; Del-Ben, Cristina Marta ^{[4, 3]} ; Louzada-Junior, Paulo ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Ctr Res Inflammatory Dis, Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Div Clin Immunol, Dept Internal Med, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto - Brazil

^[3] Populat Mental Hlth Res Ctr, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Div Psychiat, Dept Neurosci & Behav, Ribeirao Preto - Brazil

^[5] Salford Royal Fdn Trust, Dept Endocrinol & Metab, Salford, Lancs - England

^[6] Univ Estadual Londrina, Dept Phys Educ, Londrina, Parana - Brazil

^[7] Univ Sao Paulo, Ribeirao Preto Med Sch, Div Nutr & Metab, Dept Hlth Sci, Ribeirao Preto - Brazil

^[8] Univ Sao Paulo, Dept Prevent Med, Fac Med, Sao Paulo - Brazil

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 10, n. 1 DEC 8 2020.
• Web of Science Citations: 0

Abstract

Investigations of plasma amino acids in early psychosis and their unaffected siblings are rare. We measured plasma amino acids involved in the co-activation of dopaminergic, GABAergic, glutamatergic, and serotoninergic neurotransmitters in first-episode psychosis (FEP) patients (n=166), unaffected siblings (n=76), and community-based controls (n=166) included in a cross-sectional study. Plasma levels of glutamic acid (GLU), glutamine, glycine, proline (PRO), tryptophan (TRP), tyrosine, serine and GABA were quantified by gas-chromatography-mass spectrometry. We used the generalized linear model adjusted by sex, age, and body mass index for group comparison and paired t-test for FEP-Sibling pairs. FEP had reduced GABA plasma levels compared to siblings and controls (p<0.05 for both). Siblings had lower GLU, Glx and PRO (p<0.05 for all) but increased TRP compared to patients and controls (p<0.05 for both). FEP patients with longer duration of pharmacological treatment and medicated only with antipsychotics had increased GLU compared to FEP with shorter periods, or with those treated with a combination of medications (p<0.05 for both). Finally, FEP patients treated only with antipsychotics presented higher Glx compared to those with mixed medications (p=0.026). Our study suggests that FEP have low a GABA plasma profile. Unaffected siblings may be a possible risk group for metabolic abnormalities. (AU)

• FAPESP's process: 13/11167-3 - Gene-environment interactions in Schizophrenia and other psychotic disorders
• Grantee: Rosana Shuhama
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/12195-9 - Impact of early life stress in the inflammatory profile of first episode of psychosis (FEP) patients and in the animal model of post-weaning social isolation
• Grantee: Fabiana Maria das Graças Corsi Zuelli
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/07581-2 - Mortality in mental disorders with recent onset psychotic manifestations
• Grantee: Daiane Leite da Roza
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/00624-5 - DNA methylation investigation in first episode of psychosis and in rats undergoing isolation rearing from weaning in the two major excitatory and inhibitory systems
• Grantee: Helene Aparecida Fachim
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 15/02948-7 - Study of epigenetic alterations in GABAergic neurotransmission in schizophrenia and other psychoses and in animals undergoing social isolation from weaning
• Grantee: Helene Aparecida Fachim
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/13229-2 - Inflammatory profile in the general population: transdiagnostic dimensions in the context of the psychosis continuum
• Grantee: Fabiana Maria das Graças Corsi Zuelli
• Support Opportunities: Scholarships in Brazil - Doctorate