Mortality in mental disorders with recent onset psychotic manifestations

• Grant number: 18/07581-2
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2018
• End date: June 29, 2022
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Agreement: Fundação Seade
• Principal Investigator: Cristina Marta Del-Ben
• Grantee: Daiane Leite da Roza
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 17/03771-9 - Mortality in mental disorders, AP.TEM

Abstract

Schizophrenia and other psychotic disorders are a serious public health problem with high morbidity and mortality (McGrath et al. Epidemiol Rev 2008,30:67-76). The few studies conducted in low- or middle-income countries and/or located in the southern hemisphere, although methodologically very heterogeneous, contradict the belief that the evolution and prognosis of psychoses would be more benign in low- and middle-income countries (Cohen et al. Schizophr Bull 2008,34:229-244). On the other hand, the relatively low incidence of first psychotic episode (15.8/100,000) observed in the city of São Paulo (Menezes et al. Br Psychiatry Suppl. 2007;51:s102-s106) suggests that mechanisms operating in rich countries may not be the same in other populations, or that variations in the prevalence of environmental risk factors among populations are, at least in part, responsible for variations in the incidence and course of mental disorders. Worldwide, the mortality rate of individuals with mental disorders is about 2 times higher than that observed in the general population or in controls, with an estimated 10 years of life lost (Walker et al., JAMA Psychiatry, 2015. 72:334 -341). However, data on low- and middle-income countries are rare, being the only study carried out in South America, published 20 years ago (Menezes & Mann. Rev Saude Publica, 1996; 30:304-309). The estimation of real mortality rates in psychosis, as well as the determination of possible protective and risk factors of these mortality rates, can contribute in a relevant way to the planning of preventive actions. (AU)

Scientific publications

(12)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

DA ROZA, DAIANE LEITE; DE REZENDE, MARCOS GONCALVES; MAIA BARROS, REGIS ERIC; DE AZEVEDO-MARQUES, JOAO MAZZONCINI; FERREIRA SANTOS, JAIR LICIO; CORREIA MORAIS, LILIAN CRISTINA; DE CARVALHO FERREIRA, CARLOS EUGENIO; WALDVOGEL, BERNADETTE CUNHA; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA. Excess mortality in a cohort of Brazilian patients with a median follow-up of 11 years after the first psychiatric hospital admission. Social Psychiatry and Psychiatric Epidemiology, v. 58, n. 2, p. 12-pg., 2022-05-31. (18/07578-1, 18/07581-2, 17/03771-9)

RAGAZZI, TACIANA C. C.; SHUHAMA, ROSANA; SINVAL, JORGE; MAROCO, JOAO; CORSI-ZUELLI, FABIANA; DA ROZA, DAIANE L.; VAN OS, JIM; MENEZES, PAULO R.; DEL-BEN, CRISTINA M.. Validation of the Portuguese version of the Community Assessment of Psychic Experiences and characterization of psychotic experiences in a Brazilian sample. Revista Brasileira de Psiquiatria, v. 42, n. 4, p. 9-pg., 2020-07-01. (19/13229-2, 12/05178-0, 18/07581-2)

DE REZENDE, MARCOS GONCALVES; EDUARDO, JULIANA ARANTES FIGUEIREDO DE PAULA; LEVI, VITORIA; DA ROZA, DAIANE LEITE; CAVALLI, RICARDO DE CARVALHO; BETTIOL, HELOISA; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA. Racial Discrimination Experiences During Pregnancy Are Associated with Suicidal Ideation in Depressed Postpartum Women. ARCHIVES OF SUICIDE RESEARCH, v. N/A, p. 16-pg., 2025-04-13. (18/07578-1, 18/07581-2, 17/03771-9)

RAGAZZI, TACIANA C. C.; SHUHAMA, ROSANA; SINVAL, JORGE; MAROCO, JOAO; CORSI-ZUELLI, FABIANA; DA ROZA, DAIANE L.; VAN OS, JIM; MENEZES, PAULO R.; DEL-BEN, CRISTINA M.. Validation of the Portuguese version of the Community Assessment of Psychic Experiences and characterization of psychotic experiences in a Brazilian sample. Revista Brasileira de Psiquiatria, v. 42, n. 4, p. 389-397, JUL-AUG 2020. (18/07581-2, 19/13229-2, 12/05178-0)

LOUREIRO, CAMILA MARCELINO; DA ROZA, DAIANE LEITE; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; FACHIM, HELENE APARECIDA; SIMOES-AMBROSIO, LIVIA MARIA CORDEIRO; DEMINICE, RAFAEL; JORDAO, ALCEU AFONSO; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA; et al. Plasma amino acids profile in first-episode psychosis, unaffected siblings and community-based controls. SCIENTIFIC REPORTS, v. 10, n. 1, DEC 8 2020. (13/11167-3, 16/12195-9, 18/07581-2, 17/00624-5, 15/02948-7, 19/13229-2)

SANTOS, M. E. S. B.; ROZA, D. L.; BARROS, R. E. M.; SANTOS, J. L. F.; RAZZOUK, D.; AZEVEDO-MARQUES, J. M.; MENEZES, P. R.; DEL-BEN, C. M.. Patient needs four years after first psychiatric hospitalization in a Brazilian cohort. Brazilian Journal of Medical and Biological Research, v. 54, n. 8, 2021. (18/07581-2)

MARIA PAULA FOSS; PAULA REJANE BESERRA DINIZ; DAIANE LEITE DA ROZA; TAMAR GEFEN; AMANDA COOK MAHER; PAULO FORMIGHERI; CARINA T. SPEDO; CARLOS ERNESTO GARRIDO SALMON; VITOR TUMAS; JOSÉ GERALDO SPECIALI; et al. Achados Anatômicos e Neuropsicológicos de Idosos Cognitivamente Saudáveis com Baixa Escolaridade em uma Coorte Brasileira. Dement. Neuropsychol., v. 13, n. 4, p. 378-385, 2019-12-09. (18/07581-2)

FIGUEIREDO DE PAULA EDUARDO, JULIANA ARANTES; FIGUEIREDO, FELIPE PINHEIRO; DE REZENDE, MARCOS GONCALVES; DA ROZA, DAIANE LEITE; DE FREITAS, STELLA FELIPPE; LUCENA BATISTA, ROSANGELA FERNANDES; MOURA DA SILVA, ANTONIO AUGUSTO; BARBIERI, MARCO ANTONIO; CAVALLI, RICARDO CARVALHO; BETTIOL, HELOISA; et al. Preterm birth and postpartum depression within 6 months after childbirth in a Brazilian cohort. ARCHIVES OF WOMENS MENTAL HEALTH, v. 25, n. 5, p. 13-pg., 2022-07-18. (18/07578-1, 18/07581-2, 08/53593-0)

PEDRAZZANI, PAULO S.; ARAUJO, TATIANA O. P.; SIGOLI, EMILLY; DA SILVA, ISABELLA R.; DA ROZA, DAIANE LEITE; CHESCA, DEISE LUCIA; RASSIER, DILSON E.; CORNACHIONE, ANABELLE S.. Twenty-one days of low-intensity eccentric training improve morphological characteristics and function of soleus muscles of mdx mice. SCIENTIFIC REPORTS, v. 11, n. 1, FEB 11 2021. (13/07104-6, 18/07581-2, 17/00267-8, 13/25634-2)

RAGAZZI, TACIANA CRISTINA CARVALHO; SHUHAMA, ROSANA; DA SILVA, PEDRO HENRIQUE RODRIGUES; CORSI-ZUELLI, FABIANA; LOUREIRO, CAMILA MARCELINO; DA ROZA, DAIANE LEITE; LEONI, RENATA FERRANTI; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA. Neurocognition and brain functional connectivity in a non-clinical population-based sample with psychotic experiences. SCHIZOPHRENIA RESEARCH, v. 267, p. 9-pg., 2024-03-27. (17/22212-0, 19/13229-2, 12/05178-0, 18/07581-2, 20/15752-1, 21/07448-3, 13/11167-3)

CORSI-ZUELLI, FABIANA; MARQUES, LEONARDO; DA ROZA, DAIANE LEITE; LOUREIRO, CAMILA MARCELINO; SHUHAMA, ROSANA; DI FORTI, MARTA; MENEZES, PAULO ROSSI; LOUZADA-JUNIOR, PAULO; DEL-BEN, CRISTINA MARTA. The independent and combined effects of cannabis use and systemic inflammation during the early stages of psychosis: exploring the two-hit hypothesis. PSYCHOLOGICAL MEDICINE, v. N/A, p. 11-pg., 2021-03-19. (12/05178-0, 13/11167-3, 13/08216-2, 19/13229-2, 18/07581-2)

. . SCIENTIFIC REPORTS, v. 11, n. 1, p. 11-pg., 2021-02-11. (13/25634-2, 13/07104-6, 18/07581-2, 17/00267-8)