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Mortality in mental disorders with recent onset psychotic manifestations

Grant number: 18/07581-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2018
Effective date (End): July 31, 2021
Field of knowledge:Health Sciences - Medicine - Psychiatry
Cooperation agreement: Fundação Seade
Principal researcher:Cristina Marta Del-Ben
Grantee:Daiane Leite da Roza
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:17/03771-9 - Mortality in mental disorders, AP.TEM

Abstract

Schizophrenia and other psychotic disorders are a serious public health problem with high morbidity and mortality (McGrath et al. Epidemiol Rev 2008,30:67-76). The few studies conducted in low- or middle-income countries and/or located in the southern hemisphere, although methodologically very heterogeneous, contradict the belief that the evolution and prognosis of psychoses would be more benign in low- and middle-income countries (Cohen et al. Schizophr Bull 2008,34:229-244). On the other hand, the relatively low incidence of first psychotic episode (15.8/100,000) observed in the city of São Paulo (Menezes et al. Br Psychiatry Suppl. 2007;51:s102-s106) suggests that mechanisms operating in rich countries may not be the same in other populations, or that variations in the prevalence of environmental risk factors among populations are, at least in part, responsible for variations in the incidence and course of mental disorders. Worldwide, the mortality rate of individuals with mental disorders is about 2 times higher than that observed in the general population or in controls, with an estimated 10 years of life lost (Walker et al., JAMA Psychiatry, 2015. 72:334 -341). However, data on low- and middle-income countries are rare, being the only study carried out in South America, published 20 years ago (Menezes & Mann. Rev Saude Publica, 1996; 30:304-309). The estimation of real mortality rates in psychosis, as well as the determination of possible protective and risk factors of these mortality rates, can contribute in a relevant way to the planning of preventive actions. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
El perfil inflamatorio puede influir en el efecto de la marihuana y en el riesgo de desarrollar psicosis 
Inflammatory profile can influence the effects of cannabis use and the risk of suffering from psychosis 
Articles published in other media outlets (27 total):
More itemsLess items
Al Día (Cuba): El perfil inflamatorio puede influir en el efecto de la marihuana y en el riesgo de desarrollar psicosis (06/Jul/2021)
Rocha al dia (Uruguai): El perfil inflamatorio puede influir en el efecto de la marihuana y en el riesgo de desarrollar psicosis (06/Jul/2021)
Infomed - Portal de la Red de Salud de Cuba (Cuba, Mayabeque): El perfil inflamatorio puede influir en el efecto de la marihuana y en el riesgo de desarrollar psicosis (05/Jul/2021)
MedMinded (Canadá): Immune system dysfunction and cannabis use linked to psychosis (22/Jun/2021)
420 Intel (Canadá): Immune system dysfunction and cannabis use linked to psychosis (22/Jun/2021)
Health Europa (Reino Unido): Immune system dysfunction and cannabis use linked to psychosis (18/Jun/2021)
Agenparl (Itália): Immune system dysfunction can modify the association between cannabis use and psychosis (17/Jun/2021)
Mirage News (Austrália): Immune system dysfunction can modify association between cannabis use and psychosis (17/Jun/2021)
La Revue Gauche: Immune system dysfunction can modify the association between cannabis use and psychosis (17/Jun/2021)
Globe Health News: Immune system dysfunction can alter the link between cannabis use and psychosis (17/Jun/2021)
Florida News Times (EUA): Immune system dysfunction can alter the association between cannabis use and psychosis (17/Jun/2021)
MediExpose (ìndia): Immune system dysfunction can modify the association between cannabis use and psychosis (17/Jun/2021)
4State News: Immune system dysfunction can modify the association between cannabis use and psychosis (17/Jun/2021)
Newspostwall (EUA): Immune system dysfunction can modify the association between cannabis use and psychosis (17/Jun/2021)
News Medical (Austrália): Immune system dysfunction can alter the link between cannabis use and psychosis (16/Jun/2021)
Medical Xpress (Reino Unido): Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Science Codex: Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Scienmag Science Magazine (Reino Unido): Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Hale Plus Hearty (Nigéria): Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Technology Alpha: Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Science News Net: Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Ground Rush Air Sports: Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Burada Biliyorum (Turquia): Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
The Health News Express: Immune system dysfunction can modify the affiliation between hashish use and psychosis (16/Jun/2021)
Dr. About: Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Therapeutic Solutions International, Inc. (EUA): Immune system dysfunction can alter the link between cannabis use and psychosis (16/Jun/2021)
InvestorsHub (EUA): Immune system dysfunction can alter the link between cannabis use and psychosis (16/Jun/2021)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEDRAZZANI, PAULO S.; ARAUJO, TATIANA O. P.; SIGOLI, EMILLY; DA SILVA, ISABELLA R.; DA ROZA, DAIANE LEITE; CHESCA, DEISE LUCIA; RASSIER, DILSON E.; CORNACHIONE, ANABELLE S. Twenty-one days of low-intensity eccentric training improve morphological characteristics and function of soleus muscles of mdx mice. SCIENTIFIC REPORTS, v. 11, n. 1 FEB 11 2021. Web of Science Citations: 0.
LOUREIRO, CAMILA MARCELINO; DA ROZA, DAIANE LEITE; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; FACHIM, HELENE APARECIDA; SIMOES-AMBROSIO, LIVIA MARIA CORDEIRO; DEMINICE, RAFAEL; JORDAO, ALCEU AFONSO; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA; LOUZADA-JUNIOR, PAULO. Plasma amino acids profile in first-episode psychosis, unaffected siblings and community-based controls. SCIENTIFIC REPORTS, v. 10, n. 1 DEC 8 2020. Web of Science Citations: 0.
RAGAZZI, TACIANA C. C.; SHUHAMA, ROSANA; SINVAL, JORGE; MAROCO, JOAO; CORSI-ZUELLI, FABIANA; DA ROZA, DAIANE L.; VAN OS, JIM; MENEZES, PAULO R.; DEL-BEN, CRISTINA M. Validation of the Portuguese version of the Community Assessment of Psychic Experiences and characterization of psychotic experiences in a Brazilian sample. Revista Brasileira de Psiquiatria, v. 42, n. 4, p. 389-397, JUL-AUG 2020. Web of Science Citations: 0.
TACIANA C.C. RAGAZZI; ROSANA SHUHAMA; JORGE SINVAL; JOÃO MARÔCO; FABIANA CORSI-ZUELLI; DAIANE L. DA ROZA; JIM VAN OS; PAULO R. MENEZES; CRISTINA M. DEL-BEN. Validation of the Portuguese version of the Community Assessment of Psychic Experiences and characterization of psychotic experiences in a Brazilian sample. Revista Brasileira de Psiquiatria, n. ahead, p. -, 2020.
TACIANA C.C. RAGAZZI; ROSANA SHUHAMA; JORGE SINVAL; JOÃO MARÔCO; FABIANA CORSI-ZUELLI; DAIANE L. DA ROZA; JIM VAN OS; PAULO R. MENEZES; CRISTINA M. DEL-BEN. Validation of the Portuguese version of the Community Assessment of Psychic Experiences and characterization of psychotic experiences in a Brazilian sample. Revista Brasileira de Psiquiatria, v. 42, n. 4, p. 389-397, Ago. 2020.
MARIA PAULA FOSS; PAULA REJANE BESERRA DINIZ; DAIANE LEITE DA ROZA; TAMAR GEFEN; AMANDA COOK MAHER; PAULO FORMIGHERI; CARINA T. SPEDO; CARLOS ERNESTO GARRIDO SALMON; VITOR TUMAS; JOSÉ GERALDO SPECIALI; ANTÔNIO CARLOS SANTOS. Anatomic and neuropsychological findings in low-educated cognitively intact elderly from a Brazilian cohort. Dement. Neuropsychol., v. 13, n. 4, p. 378-385, Dez. 2019.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.