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Mortality in mental disorders with recent onset psychotic manifestations

Grant number: 18/07581-2
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2018
Effective date (End): June 29, 2022
Field of knowledge:Health Sciences - Medicine - Psychiatry
Acordo de Cooperação: Fundação Seade
Principal Investigator:Cristina Marta Del-Ben
Grantee:Daiane Leite da Roza
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:17/03771-9 - Mortality in mental disorders, AP.TEM


Schizophrenia and other psychotic disorders are a serious public health problem with high morbidity and mortality (McGrath et al. Epidemiol Rev 2008,30:67-76). The few studies conducted in low- or middle-income countries and/or located in the southern hemisphere, although methodologically very heterogeneous, contradict the belief that the evolution and prognosis of psychoses would be more benign in low- and middle-income countries (Cohen et al. Schizophr Bull 2008,34:229-244). On the other hand, the relatively low incidence of first psychotic episode (15.8/100,000) observed in the city of São Paulo (Menezes et al. Br Psychiatry Suppl. 2007;51:s102-s106) suggests that mechanisms operating in rich countries may not be the same in other populations, or that variations in the prevalence of environmental risk factors among populations are, at least in part, responsible for variations in the incidence and course of mental disorders. Worldwide, the mortality rate of individuals with mental disorders is about 2 times higher than that observed in the general population or in controls, with an estimated 10 years of life lost (Walker et al., JAMA Psychiatry, 2015. 72:334 -341). However, data on low- and middle-income countries are rare, being the only study carried out in South America, published 20 years ago (Menezes & Mann. Rev Saude Publica, 1996; 30:304-309). The estimation of real mortality rates in psychosis, as well as the determination of possible protective and risk factors of these mortality rates, can contribute in a relevant way to the planning of preventive actions. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RAGAZZI, TACIANA C. C.; SHUHAMA, ROSANA; SINVAL, JORGE; MAROCO, JOAO; CORSI-ZUELLI, FABIANA; DA ROZA, DAIANE L.; VAN OS, JIM; MENEZES, PAULO R.; DEL-BEN, CRISTINA M.. Validation of the Portuguese version of the Community Assessment of Psychic Experiences and characterization of psychotic experiences in a Brazilian sample. Revista Brasileira de Psiquiatria, v. 42, n. 4, p. 389-397, . (18/07581-2, 19/13229-2, 12/05178-0)
SANTOS, M. E. S. B.; ROZA, D. L.; BARROS, R. E. M.; SANTOS, J. L. F.; RAZZOUK, D.; AZEVEDO-MARQUES, J. M.; MENEZES, P. R.; DEL-BEN, C. M.. Patient needs four years after first psychiatric hospitalization in a Brazilian cohort. Brazilian Journal of Medical and Biological Research, v. 54, n. 8, . (18/07581-2)
LOUREIRO, CAMILA MARCELINO; DA ROZA, DAIANE LEITE; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; FACHIM, HELENE APARECIDA; SIMOES-AMBROSIO, LIVIA MARIA CORDEIRO; DEMINICE, RAFAEL; JORDAO, ALCEU AFONSO; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA; et al. Plasma amino acids profile in first-episode psychosis, unaffected siblings and community-based controls. SCIENTIFIC REPORTS, v. 10, n. 1, . (13/11167-3, 16/12195-9, 18/07581-2, 17/00624-5, 15/02948-7, 19/13229-2)
PEDRAZZANI, PAULO S.; ARAUJO, TATIANA O. P.; SIGOLI, EMILLY; DA SILVA, ISABELLA R.; DA ROZA, DAIANE LEITE; CHESCA, DEISE LUCIA; RASSIER, DILSON E.; CORNACHIONE, ANABELLE S.. Twenty-one days of low-intensity eccentric training improve morphological characteristics and function of soleus muscles of mdx mice. SCIENTIFIC REPORTS, v. 11, n. 1, . (17/03843-0, 13/07104-6, 18/07581-2, 17/00267-8, 16/21048-0, 13/25634-2)
MARIA PAULA FOSS; PAULA REJANE BESERRA DINIZ; DAIANE LEITE DA ROZA; TAMAR GEFEN; AMANDA COOK MAHER; PAULO FORMIGHERI; CARINA T. SPEDO; CARLOS ERNESTO GARRIDO SALMON; VITOR TUMAS; JOSÉ GERALDO SPECIALI; et al. Achados Anatômicos e Neuropsicológicos de Idosos Cognitivamente Saudáveis com Baixa Escolaridade em uma Coorte Brasileira. Dement. Neuropsychol., v. 13, n. 4, p. 378-385, . (18/07581-2)

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