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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dorsal hippocampus plays a causal role in context-induced reinstatement of alcohol-seeking in rats

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Author(s):
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Felipe, Jaqueline Moreira [1] ; Palombo, Paola [1] ; Bianchi, Paula Cristina [1] ; Zaniboni, Caroline Riberti [1] ; Anesio, Augusto [1] ; Yokoyama, Thais Suemi [1] ; Engi, Sheila Antonagi [1] ; Carneiro-de-Oliveira, Paulo Eduardo [2] ; Planeta, Cleopatra da Silva [3] ; Leao, Rodrigo Molini [4] ; Cruz, Fabio Cardoso [1]
Total Authors: 11
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Pharmacol, BR-04023062 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Carlos UFSCar, Psychol Lab, Dept Psychol, BR-13565905 Sao Carlos, SP - Brazil
[3] Sao Paulo State Univ Unesp, Pharmacol Lab, Sch Pharmaceut Sci, Araraquara, SP - Brazil
[4] Univ Fed Uberlandia UFU, Inst Biomed Sci, BR-38400902 Uberlandia, MG - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Behavioural Brain Research; v. 398, FEB 1 2021.
Web of Science Citations: 1
Abstract

Drug addiction is a chronic mental disorder characterized by frequent relapses. Contextual cues associated with drug use to play a critical causal role in drug-seeking behavior. The hippocampus has been implicated in encoding drug associative memories. Here we examine whether the dorsal hippocampus mediates context induced reinstatement of alcohol-seeking. Male Long-Evans rats were trained to self-administer alcohol in Context A. Alcohol self-administration was extinguished in a distinct context (Context B). On the test day, animals were re-exposed to the alcohol Context A or the extinction Context B. Next, to assess a causal role for the dorsal hippocampus in context-induced alcohol-seeking, on the test day, we injected cobalt chloride (CoCl2; a nonselective synapse inhibitor) or vehicle into the dorsal hippocampus, and 15 min later, rats were tested by re exposing them to the drug-associated context. The re-exposure to the alcohol-associated Context A reinstated alcohol seeking and increased Fos-positive cells in the dorsal hippocampus neurons (CA1, CA3, and Dentate Gyrus). Pharmacological inactivation with cobalt chloride of the dorsal hippocampus attenuated the reinstatement of alcohol-seeking. Our data suggest that the dorsal hippocampus may be involved in context-induced alcohol-seeking behavior. (AU)

FAPESP's process: 18/15505-4 - Neurobiology study of relapse to alcohol and cocaine seeking: identification of plasticity in neuronal ensembles that encodes addiction-related memories
Grantee:Fabio Cardoso Cruz
Support Opportunities: Research Grants - Young Investigators Grants - Phase 2