Lidocaine administered at a continuous rate infusion does not impair left ventricular systolic and diastolic function of healthy rabbits sedated with midazolam

Author(s):Show less -

Marques, A. E. G. W. ^[1] ; Marques, M. G. ^{[1, 2]} ; Silveira, B. C. R. ^[1] ; Oliveira, S. P. ^[1] ; Ferraz, I. G. ^[1] ; Ventricci, A. B. G. ^[2] ; Silva, N. C. ^[1] ; Nagata, W. B. ^[1] ; Floriano, B. P. ^[2] ; Ferreira, W. L. ^[1] ; Santos, P. S. P. ^[1]

Affiliation

^[1] Sao Paulo State Univ, UNESP, Sch Vet Med, Dept Anim Clin Surg & Reprod, 793 Clovis Pestana St, BR-16050680 Aracatuba, SP - Brazil

^[2] Univ Ctr Integrated Coll Ourinhos UniFio, Dept Vet Med, BR 153, Km 338 420m, BR-19909100 Ourinhos, SP - Brazil

• Document type: Journal article
• Source: VETERINARY AND ANIMAL SCIENCE; v. 10, DEC 2020.
• Web of Science Citations: 0

Abstract

Lidocaine is a versatile drug that not only provides local anesthesia, but also reduces anesthetic requirements of other agents and has antiarrhythmic, pro-kinetic, anti-inflammatory, antiendotoxemic and antioxidant effects. As it is a drug commonly used in critically ill patients, its safety from the cardiovascular system should be ensured. The aim of this study was to determine the effects of a continuous rate infusion (CRI) of lidocaine on left ventricular systolic and diastolic function of healthy rabbits sedated with midazolam by use of transthoracic echocardiography. Ten New Zealand healthy rabbits were sedated with intramuscular midazolam (1 mg/kg) and enrolled in two experimental treatments (control or lidocaine). The control treatment (CT) comprised an intravenous bolus of 0.9% sodium chloride (0.05 mL/kg) followed by CRI at 5 mL/h, whereas the lidocaine treatment (LT) comprised a bolus of 2% lidocaine without epinephrine at 1 mg/kg followed by CRI at 50 mu g/kg/minute. Echocardiographic and hemodynamic variables were studied. Variables were recorded at baseline (TB) and 20, 40 and 60 minutes following start of CRI (T20, T40 and T60, respectively). No differences were found between treatments. The results of this study demonstrate that a continuous rate infusion of lidocaine at 50 mu g/kg/minute does not impair echocardiographic indices of left ventricular systolic and diastolic function of healthy rabbits sedated with midazolam. (AU)

• FAPESP's process: 17/20513-3 - Ecocardiographic evaluation of rabbits sibmitted to continuous infusion of lidocaine sedated with midazolam
• Grantee: Ana Elisa Gregui Watanabe Marques
• Support Opportunities: Scholarships in Brazil - Master