Effect of high-intensity exercise on cerebral, respiratory and peripheral muscle oxygenation of HF and COPD-HF patients

Author(s):Show less -

Goulart, Cassia Luz ^[1] ; Tinoco Areas, Guilherme Peixoto ^{[1, 2]} ; Caruso, Flavia Rossi ^[1] ; Garcia Araujo, Adriana S. ^[1] ; Garcia de Moura, Silvia Cristina ^[3] ; Catai, Aparecida Maria ^[3] ; Beltrame, Thomas ^[3] ; de Carvalho Junior, Luiz Carlos ^[1] ; dos Santos, Polliana Batista ^[1] ; Roscani, Meliza Goi ^[4] ; Mendes, Renata Goncalves ^[1] ; Arena, Ross ^[5] ; Borghi-Silva, Audrey ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Physiotherapy Dept, Cardiopulm Physiotherapy Lab, UFSCar, Rodovia Washington Luis, KM 235, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Amazonas, UFAM, Physiol Dept, Human Physiol Lab, V Gen Rodrigo Octavio 6200, Coroado 1, BR-69080900 Manaus, Amazonas - Brazil

^[3] Univ Fed Sao Carlos, Physiotherapy Dept, Cardiovasc Phys Therapy Lab, Rod Washington Luis, KM 235, BR-13565905 Sao Carlos, SP - Brazil

^[4] Univ Fed Sao Carlos, Dept Med, Sao Carlos, SP - Brazil

^[5] Univ Illinois, Dept Phys Therapy, Coll Appl Hlth Sci, Chicago, IL - USA

• Document type: Journal article
• Source: HEART & LUNG; v. 50, n. 1, p. 113-120, JAN-FEB 2021.
• Web of Science Citations: 1

Abstract

Objective: To investigate cerebral oxygenation (Cox) responses as well as respiratory (Res) and active peripheral muscle (Pm) O-2 delivery during high-intensity cycling exercise and contrast responses between patients with coexistent chronic obstructive pulmonary disease (COPD)-heart failure (HF) and HF alone. Methods: Cross-sectional study involving 11 COPD-HF and 11 HF patients. On two different days, patients performed maximal incremental cardiopulmonary exercise testing (CPET) and constant load exercise on a cycle ergometer until the limit of tolerance (Tlim). The high-intensity exercise session was 80% of the peak CPET work rate. Relative blood concentrations of oxyhemoglobin ({[}O(2)Hb]), deoxyhemoglobin ({[}HHb]) of Res, Pm (right vastus lateralis) and Cox (pre-frontal) were measured using near infrared spectroscopy. Results: We observed a greater decrease in {[}O(2)Hb] at a lower Tlim in COPD-HF when compared to HF (P < 0.05). {[}HHb] of Res was higher (P < 0.05) and Tlim was lower in COPD-HF vs. HF. Pm and Cox were lower and Tlim was higher in (P < 0.05) HF vs. COPD-HF. In HF, there was a lower Delta{[}O(2)Hb] and higher A {[}HHb] of Pm when contrasted to Cox observed during exercise, as well as a lower Delta{[}O(2)Hb] and higher Delta {[}HHb] of Res when contrasted with Cox (P < 0.05). However, COPD-HF patients presented with a higher Delta {[}HHb] of Res and Pm when contrasted with Cox (P < 0.05). Conclusion: The coexistence of COPD in patients with HF produces negative effects on Cox, greater deoxygenation of the respiratory and peripheral muscles and higher exertional dyspnea, which may help to explain an even lower exercise tolerance in this multimorbidity phenotype. (C) 2020 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 15/26501-1 - Study of limiting factors to physical exercise and adjunct effects to rehabilitation on cardiorespiratory disease: a multicentre approach
• Grantee: Audrey Borghi Silva
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/03233-0 - Study of cardiorespiratory interaction and the supply of peripheral and cerebral oxygen as modulators of exercise capacity during bilevel application in the coexistence of COPD-CHF
• Grantee: Cássia da Luz Goulart
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)