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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biochemical phenotyping of multiple myeloma patients at diagnosis reveals a disorder of mitochondrial complexes I and II and a Hartnup-like disturbance as underlying conditions, also influencing different stages of the disease

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Author(s):
Cotrim Guerreiro da Silva, Ismael Dale [1] ; de Castro Levatti, Erica Valadares [2] ; Pedroso, Amanda Paula [3] ; Lobo Marchioni, Dirce Maria [4] ; Ferreira Carioca, Antonio Augusto [4, 5] ; Braga Colleoni, Gisele Wally [2]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Paulista Sch Med, Dept Gynecol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Paulista Sch Med, Dept Clin & Expt Oncol, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Paulista Sch Med, Dept Physiol, Sao Paulo - Brazil
[4] Univ Sao Paulo MUSP, Sch Publ Hlth, Nutr Dept, Sao Paulo - Brazil
[5] Univ Fortaleza UNIFOR, Nutr Dept, Fortaleza, Ceara - Brazil
Total Affiliations: 5
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 10, n. 1 DEC 14 2020.
Web of Science Citations: 0
Abstract

The aim of this study was to identify novel plasma metabolic signatures with possible relevance during multiple myeloma (MM) development and progression. A biochemical quantitative phenotyping platform based on targeted electrospray ionization tandem mass spectrometry technology was used to aid in the identification of any eventual perturbed biochemical pathway in peripheral blood plasma from 36 MM patients and 73 healthy controls. Our results showed that MM cases present an increase in short and medium/long-chain species of acylcarnitines resembling Multiple AcylCoA Dehydrogenase Deficiency (MADD), particularly, associated with MM advanced International Staging System (ISS). Lipids profile showed lower concentrations of phosphatidylcholine (PC), lysophosphatidylcholine (LPC) and sphingomyelins (SM) in the MM patients and its respective ISS groups. MM cases were accompanied by a drop in the concentration of essential amino acids, especially tryptophan, with a significant inverse correlation between the progressive drop in tryptophan with the elevation of beta 2-microglobulin, with the increase in systemic methylation levels (Symmetric Arginine Dimethylation, SDMA) and with the accumulation of esterified carnitines in relation to free carnitine (AcylC/C0). Serotonin was significantly elevated in cases of MM, without a clear association with ISS. Kynurenine/tryptophan ratio demonstrates that the activity of dioxigenases is even higher in the cases classified as ISS 3. In conclusion, our study showed that MM patients at diagnosis showed metabolic disorders resembling both mitochondrial complexes I and II and Hartnup-like disturbances as underlying conditions, also influencing different stages of the disease. (AU)

FAPESP's process: 17/21801-2 - Predictors of severity and new treatments for bone marrow neoplasias
Grantee:Sara Teresinha Olalla Saad
Support type: Research Projects - Thematic Grants
FAPESP's process: 10/17668-6 - Identification of biomarkers and possible therapeutical targets in B-cell lymphoproliferative disorders
Grantee:Gisele Wally Braga Colleoni
Support type: Research Projects - Thematic Grants