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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Rotaxanating Metallo-supramolecular Nano-cylinder Helicates to Switch DNA Junction Binding

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Hooper, Catherine A. J. [1] ; Cardo, Lucia [1] ; Craig, James S. [2] ; Melidis, Lazaros [2] ; Garai, Aditya [1] ; Egan, Ross T. [1] ; Sadovnikova, Viktoriia [1] ; Burkert, Florian [1] ; Male, Louise [1] ; Hodges, Nikolas J. [1] ; Browning, Douglas F. [1] ; Rosas, Roselyne [3] ; Liu, Fengbo [4] ; Rocha, V, Fillipe ; Lima, Mauro A. [5] ; Liu, Simin [4] ; Bardelang, David [6] ; Hannon, Michael J. [1, 2]
Total Authors: 18
[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands - England
[2] Univ Birmingham, Phys Sci Hlth Ctr, Birmingham B15 2TT, W Midlands - England
[3] Aix Marseille Univ, FSCM, Cent Marseille, CNRS, Spectropole, F-13007 Marseille - France
[4] Wuhan Univ Sci & Technol, State Key Lab Refractories & Met, Sch Chem & Chem Engn, Wuhan 430081 - Peoples R China
[5] Rocha, Fillipe, V, Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos - Brazil
[6] Aix Marseille Univ, ICI, CNRS, F-13013 Marseille - France
Total Affiliations: 6
Document type: Journal article
Source: Journal of the American Chemical Society; v. 142, n. 49, p. 20651-20660, DEC 9 2020.
Web of Science Citations: 0

A class of rotaxane is created, not by encapsulating a conventional linear thread, but rather by wrapping a large cucurbit{[}10]uril macrocycle about a three-dimensional, cylindrical, nanosized, self-assembled supramolecular helicate as the axle. The resulting pseudo-rotaxane is readily converted into a proper interlocked rotaxane by adding branch points to the helicate strands that form the surface of the cylinder (like branches and roots on a tree trunk). The supramolecular cylinder that forms the axle is itself a member of a unique and remarkable class of helicate metallo-drugs that bind Y-shaped DNA junction structures and induce cell death. While pseudo-rotaxanation does not modify the DNA-binding properties, proper, mechanically-interlocked rotaxanation transforms the DNA-binding and biological activity of the cylinder. The ability of the cylinder to de-thread from the rotaxane (and thus to bind DNA junction structures) is controlled by the extent of branching: fully-branched cylinders are locked inside the cucurbit{[}10]uril macrocycle, while cylinders with incomplete branch points can de-thread from the rotaxane in response to competitor guests. The number of branch points can thus afford kinetic control over the drug de-threading and release. (AU)

FAPESP's process: 19/11242-1 - Relative quantification of DNA-Topoisomerases enzymes in cell lines: Correlation between cytotoxicity and mechanism of action of coordination compounds
Grantee:Fillipe Vieira Rocha
Support type: Regular Research Grants