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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thermal characterization and stability investigation of sericin and alginate blend loaded with diclofenac sodium or ibuprofen

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Author(s):
Freitas, Emanuelle D. [1] ; Vidart, Jacyara M. M. [1] ; da Silva, Meuris G. C. [1] ; Vieira, Melissa G. A. [1]
Total Authors: 4
Affiliation:
[1] Univ Campinas UNICAMP, Sch Chem Engn, Dept Proc & Prod Design, Albert Einstein Ave 500, BR-13083852 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: EUROPEAN POLYMER JOURNAL; v. 142, JAN 5 2021.
Web of Science Citations: 0
Abstract

Developing new pharmaceutical forms from existing drugs has proven to be an alternative in the face of economic and temporal challenges to develop new drugs. In this work, thermal behavior of diclofenac sodium or ibuprofen loaded sericin and alginate particles was evaluated. The thermal phenomena were verified by Thermogravimetric Analysis, Differential Thermal Analysis and Differential Scanning Calorimetry. In addition, the analysis of Hot Stage Microscopy was performed to visualize the thermal phenomena. It was verified that the drugs maintained their original thermal characteristics after their incorporation, which demonstrates no significant interactions between the drugs and the polymeric matrix. The micrographs of Hot Stage Microscopy showed that the drug remains trapped in the particles, even after its melting. The diclofenac sodium particles were also subjected to the accelerated stability test under forced storage conditions (40 +/- 2 degrees C and 75 +/- 5% relative humidity) for 6 months, being evaluated the parameters of incorporation efficiency and release of drug in simulated enteric media, after the storage. Considering the results, the particles remained stable in the studied storage conditions, with reproducible incorporation efficiency and release tests. (AU)

FAPESP's process: 15/13505-9 - INCORPORATION AND RELEASE OF DRUGS BY SERICIN-ALGINATE MICROPARTICLES
Grantee:Melissa Gurgel Adeodato Vieira
Support Opportunities: Regular Research Grants
FAPESP's process: 16/05007-1 - Removal of residual drug in aqueous solution by alternative adsorbents
Grantee:Meuris Gurgel Carlos da Silva
Support Opportunities: Regular Research Grants