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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of silicon, strontium and aluminum oxides on silicon nitride ceramics for bone replacements

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Author(s):
do Nascimento, Sergio Ferreira [1] ; Dorion Rodas, Andrea Cecilia [2] ; de Souza Carvalho, Flavio Machado [3] ; Higa, Olga Zazuco [1] ; Guedes e Silva, Cecilia Chaves [1]
Total Authors: 5
Affiliation:
[1] Inst Pesquisas Energet & Nucl, Ave Prof Lineu Prestes 2242, Sao Paulo, SP - Brazil
[2] Univ Fed ABC, Ctr Engn Modelagem & Ciencias Sociais Aplicadas, Alameda Univ S-N, Sao Bernardo Do Campo, SP - Brazil
[3] Univ Sao Paulo, Rua Lago 562, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: MATERIA-RIO DE JANEIRO; v. 25, n. 4 2020.
Web of Science Citations: 0
Abstract

Although silicon nitride ceramics have been shown very propitious to be used for bone replacements, some characteristics can be controlled to improve their osseointegrations process. One of them is the intergranular phase whose composition can be specified to stimulate mineralization and osteoblastic production. In this paper, the intergranular glassy phase was projected in order to contain silicon, strontium and aluminum oxides. Silicon nitride samples containing different contents of SiO2, SrO and Al2O3 were sintered at 1815 degrees C for 1 hour and characterized by scanning electron microscopy and X-ray diffraction. Hardness and fracture toughness were determined by Vickers hardness test and compressive strength was evaluated using an universal material testing machine. The biological behavior was studied in regard to cytotoxicity and cell proliferation by means of in vitro experiments. The samples reached high densities (higher than 95 %TD), total alpha ->beta-Si3N4 transformation, fracture toughness higher than 6.5 MPa.m(1/2), compressive strength up to 2500 MPa and Vickers hardness less than 9.8 GPa. All samples were non-cytotoxic and able to promote cell proliferation with great potential to be used as components for bone replacements. However, that sample with high content of strontium had the best results of cell proliferation, proving the importance of a careful choice of intergranular phase composition in silicon nitride ceramics. (AU)

FAPESP's process: 15/02265-7 - Development of ceramic composites of Si3N4-SiO2-CaO system for bone compatibility
Grantee:Cecília Chaves Guedes e Silva
Support Opportunities: Regular Research Grants