Thermodynamic assessment of therapeutic hypothermia techniques for rehabilitation of post-cardiac arrest patients

Author(s)

Alves, Ellen Cavalcante ^[1] ; Keutenedjian Mady, Carlos Eduardo ^[1]

Affiliation

^[1] Univ Estadual Campinas, Sch Mech Engn, Mendeleyev St 200, Cidade Univ, BR-13083970 Campinas - Brazil

• Document type: Journal article
• Source: CASE STUDIES IN THERMAL ENGINEERING; v. 22, DEC 2020.
• Web of Science Citations: 0

Abstract

A comparative study of the three main methods for inducing hypothermia in post-cardiac arrest patients is performed. A human thermal model from the literature is adapted to simulate an average adult during treatment using intravascular cooling, extracorporeal cooling, or a combination of both. The investigation is carried out using the temperature profile that best represents the hypothalamus temperature, and uses the destroyed exergy as a quality index. Each of these techniques is modeled by an equation for the exergy efficiency. As a result of the better stability and control of the patient's core temperature, as well as a reduction of destroyed exergy, the model that makes use of both techniques simultaneously proves to be, from a thermodynamic perspective, superior to the others, although each has advantages and disadvantages. (AU)

• FAPESP's process: 15/22883-7 - Thermodynamics analysis applied to biological systems
• Grantee: Carlos Eduardo Keutenedjian Mady
• Support Opportunities: Regular Research Grants