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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Intracellular Ca2+ Signaling in Protozoan Parasites: An Overview with a Focus on Mitochondria

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Author(s):
Scarpelli, Pedro H. [1] ; Pecenin, Mateus F. [1] ; Garcia, Celia R. S. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Ave Prof Lineu Prestes, 580, Bloco 17, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 1 JAN 2021.
Web of Science Citations: 1
Abstract

Ca2+ signaling has been involved in controling critical cellular functions such as activation of proteases, cell death, and cell cycle control. The endoplasmatic reticulum plays a significant role in Ca2+ storage inside the cell, but mitochondria have long been recognized as a fundamental Ca2+ pool. Protozoan parasites such as Plasmodium falciparum, Toxoplasma gondii, and Trypanosoma cruzi display a Ca2+ signaling toolkit with similarities to higher eukaryotes, including the participation of mitochondria in Ca2+-dependent signaling events. This review summarizes the most recent knowledge in mitochondrial Ca2+ signaling in protozoan parasites, focusing on the mechanism involved in mitochondrial Ca2+ uptake by pathogenic protists. (AU)

FAPESP's process: 17/08684-7 - Decoding Plasmodium signaling at molecular level as a new tool to the development of new antimalarials
Grantee:Célia Regina da Silva Garcia
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/07177-7 - EMU concedido no processo 2011/51295-5: image system
Grantee:Célia Regina da Silva Garcia
Support Opportunities: Multi-user Equipment Program