| Full text | |
| Author(s): |
Nakahara, Thiago S.
[1, 2]
;
Camargo, Antonio P.
[1, 2]
;
Magalhaes, Pedro H. M.
[1, 2]
;
Souza, Mateus A. A.
[1, 2]
;
Ribeiro, Pedro G.
[1, 2]
;
Martins-Netto, Paulo H.
[1, 2]
;
Carvalho, Vinicius M. A.
[1, 2]
;
Jose, Juliana
[2]
;
Papes, Fabio
[2]
Total Authors: 9
|
| Affiliation: | [1] Univ Estadual Campinas, Inst Biol, Grad Program Genet & Mol Biol, Rua Monteiro Lobato, BR-13083862 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Rua Monteiro Lobato, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 10, n. 1 NOV 17 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Behaviors are shaped by hormones, which may act either by changing brain circuits or by modifying sensory detection of relevant cues. Pup-directed behaviors have been previously shown to change via action of hormones at the brain level. Here, we investigated hormonal control of pup-induced activity in the vomeronasal organ, an olfactory sensory structure involved in the detection of non-volatile chemosignals. Vomeronasal activity decreases as males switch from a pup-aggressive state to a non-aggressive parenting state, after they socially contact a female. RNA sequencing, qPCR, and in situ hybridization were used to identify expression, in the vomeronasal sensory epithelium, of candidate GPCR hormone receptors chosen by in silico analyses and educated guesses. After identifying that oxytocin and vasopressin receptors are expressed in the vomeronasal organ, we injected the corresponding hormones in mice and showed that oxytocin administration reduced both pup-induced vomeronasal activity and aggressive behavior. Conversely, injection of an oxytocin receptor antagonist in female-primed male animals, which normally exhibit reduced vomeronasal activity, significantly increased the number of active vomeronasal neurons. These data link oxytocin to the modulation of olfactory sensory activity, providing a possible mechanism for changes in male behavior after social experience with females. (AU) | |
| FAPESP's process: | 16/05379-6 - Analysis of the lincRNA transcriptome in the accessory olfactory system |
| Grantee: | Antônio Pedro de Castello Branco da Rocha Camargo |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 15/50371-0 - Mechanisms underkying how social experience alters hormone levels, sensory signaling and behavior |
| Grantee: | Fabio Papes |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/03372-6 - Molecular and functional investigation of Polycomb Group proteins and their involvement in olfactory neurogenesis |
| Grantee: | Mateus Augusto de Andrade Souza |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/21786-0 - Ascertainment and analysis of olfactory maps in the brain |
| Grantee: | Vinicius Miessler de Andrade Carvalho |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 16/03641-5 - Investigation of hormonal modulation of instinctive behaviors mediated by olfaction |
| Grantee: | Pedro Henrique Mello Magalhães |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 12/04026-1 - Functional and Molecular Characterization of OR class receptors expressed in the mammalian Vomeronasal Organ. |
| Grantee: | Thiago Seike Picoreti Nakahara |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 17/01571-2 - Neurobioligical investigation of olaction-mediated modulation in fertility |
| Grantee: | Pedro de Gusmão Ribeiro |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |