| Full text | |
| Author(s): |
Vattimo, Edoardo F. Q.
[1]
;
dos Santos, Allan Christiano
[1]
;
Hoexter, Marcelo Q.
[1]
;
Frudit, Paula
[2]
;
Miguel, Euripedes C.
[1]
;
Shavitt, Roseli G.
[1]
;
Batistuzzo, Marcelo C.
[1, 3]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med, Dept Psiquiatria, R Dr Ovidio Pires de Campos 785, BR-01060970 Sao Paulo, SP - Brazil
[2] Fac Ciencias Med Santa Casa Sao Paulo, Sao Paulo, SP - Brazil
[3] Pontificia Univ Catolica Sao Paulo, Fac Ciencias Humanas & Saude, Curso Psicol, Dept Metodos & Tecn, Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | PSYCHIATRY RESEARCH-NEUROIMAGING; v. 307, JAN 30 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Differences in hippocampus volume have been identified in adult patients with obsessive-compulsive disorder (OCD). However, the role of this limbic structure in pediatric patients is unclear. This study aimed to investigate the hippocampus and its subregions in a sample of 29 children and adolescents with OCD compared to 28 healthy controls, matched for age, sex, education, and IQ. Volumetric segmentation was performed using the Freesurfer software to calculate the volumes of the subregions that reflect the hippocampal cytoarchitecture. The volumes of three anatomic subregions (tail, body, and head) were also calculated. ANCOVA was performed to investigate differences of these volumes between patients and controls, controlling for total gray matter volume. After Bonferroni correction for multiple comparisons (p-value < 0.00556 for the body and < 0.00625 for the head structures), patients presented statistically significant larger volumes of the following structures: left subiculum body; left CA4 body; left GC-DG body; left molecular layer body; right parasubiculum; left CA4 head; left molecular layer head; right subiculum head and right molecular layer head. These enlarged volumes resulted in larger left and right whole hippocampi in patients, as well as bilateral hippocampal heads and left hippocampal body (all p-values < 0.00625). There were no associations between OCD severity and hippocampal volumes. These findings diverge from previous reports on adults and may indicate that larger hippocampal volumes could reflect an early marker of OCD, not present in adults. (AU) | |
| FAPESP's process: | 09/09949-8 - Episodic verbal memory associated with brain activation in Obsessive-Compulsive Disorder (OCD): functional magnetic resonance imaging analysis |
| Grantee: | Marcelo Camargo Batistuzzo |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 13/08531-5 - High risk cohort study for psychiatric disorders in childhood: 3-year follow-up neuroimaging study |
| Grantee: | Andrea Parolin Jackowski |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/50917-0 - INCT 2014: developmental psychiatry for children and adolescents |
| Grantee: | Eurípedes Constantino Miguel Filho |
| Support Opportunities: | Research Projects - Thematic Grants |