| Full text | |
| Author(s): Show less - |
Leao, Tiago
[1, 2]
;
Wang, Mingxun
[1]
;
Moss, Nathan
[2]
;
da Silva, Ricardo
[1, 3]
;
Sanders, Jon
[4, 5, 6]
;
Nurk, Sergey
[7]
;
Gurevich, Alexey
[7]
;
Humphrey, Gregory
[4, 5]
;
Reher, Raphael
[2]
;
Zhu, Qiyun
[4, 5, 8]
;
Belda-Ferre, Pedro
[4, 5]
;
Glukhov, Evgenia
[2]
;
Whitner, Syrena
[2, 9]
;
Alexander, Kelsey L.
[10, 2]
;
Rex, Robert
[2]
;
Pevzner, Pavel
[11]
;
Dorrestein, Pieter C.
[1, 5, 2]
;
Knight, Rob
[12, 4, 5]
;
Bandeira, Nuno
[1, 11]
;
Gerwick, William H.
[1, 2]
;
Gerwick, Lena
[2]
Total Authors: 21
|
| Affiliation: Show less - | [1] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 - USA
[2] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92037 - USA
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, NPPNS, BR-14040900 Ribeirao Preto - Brazil
[4] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 - USA
[5] Univ Calif San Diego, Ctr Microbiome Innovat, La Jolla, CA 92093 - USA
[6] Cornell Univ, Cornell Inst Host Microbe Interact & Dis, Ithaca, NY 14850 - USA
[7] St Petersburg State Univ, Ctr Algorithm Biotechnol, St Petersburg 199004 - Russia
[8] Arizona State Univ, Sch Life Sci, Tempe, AZ 85281 - USA
[9] Univ Hawaii, Sch Life Sci, Honolulu, HI 96822 - USA
[10] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 - USA
[11] Univ Calif San Diego, Dept Comp Sci & Engn, La Jolla, CA 92093 - USA
[12] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 - USA
Total Affiliations: 12
|
| Document type: | Journal article |
| Source: | MARINE DRUGS; v. 19, n. 1 JAN 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Microbial natural products are important for the understanding of microbial interactions, chemical defense and communication, and have also served as an inspirational source for numerous pharmaceutical drugs. Tropical marine cyanobacteria have been highlighted as a great source of new natural products, however, few reports have appeared wherein a multi-omics approach has been used to study their natural products potential (i.e., reports are often focused on an individual natural product and its biosynthesis). This study focuses on describing the natural product genetic potential as well as the expressed natural product molecules in benthic tropical cyanobacteria. We collected from several sites around the world and sequenced the genomes of 24 tropical filamentous marine cyanobacteria. The informatics program antiSMASH was used to annotate the major classes of gene clusters. BiG-SCAPE phylum-wide analysis revealed the most promising strains for natural product discovery among these cyanobacteria. LCMS/MS-based metabolomics highlighted the most abundant molecules and molecular classes among 10 of these marine cyanobacterial samples. We observed that despite many genes encoding for peptidic natural products, peptides were not as abundant as lipids and lipopeptides in the chemical extracts. Our results highlight a number of highly interesting biosynthetic gene clusters for genome mining among these cyanobacterial samples. (AU) | |
| FAPESP's process: | 19/05026-4 - Development of a computational platform extensible and modular for analysis of metabolomics and metagenomics experiments: Innovating with the discovery of new enzymatic activities and derived natural products of interest |
| Grantee: | Ricardo Roberto da Silva |
| Support Opportunities: | Scholarships in Brazil - BIOTA - Young Researchers |