Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Environmental enrichment prevents the late effect of acute stress-induced fear extinction deficit: the role of hippocampal AMPA-GluA1 phosphorylation

Full text
Author(s):
Novaes, Leonardo Santana [1] ; Bueno-de-Camargo, Leticia Morais [1] ; Munhoz, Carolina Demarchi [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Dept Pharmacol, Inst Ciencias Biomed, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: TRANSLATIONAL PSYCHIATRY; v. 11, n. 1 JAN 5 2021.
Web of Science Citations: 0
Abstract

The persistence of anxiety and the deficit of fear memory extinction are both phenomena related to the symptoms of a trauma-related disorder, such as post-traumatic stress disorder (PTSD). Recently we have shown that single acute restraint stress (2h) in rats induces a late anxiety-related behavior (observed ten days after stress), whereas, in the present work, we found that the same stress impaired fear extinction in animals conditioned ten days after stress. Fourteen days of environmental enrichment (EE) prevented the deleterious effect of stress on fear memory extinction. Additionally, we observed that EE prevented the stress-induced increase in AMPA receptor GluA1 subunit phosphorylation in the hippocampus, but not in the basolateral amygdala complex and the frontal cortex, indicating a potential mechanism by which it exerts its protective effect against the stress-induced behavioral outcome. (AU)

FAPESP's process: 18/19599-3 - The role of glucocorticoids and the vagus nerve afferences on the neuronal activity and plasticity of central circuits and their implications for stress-induced anxiety in rats
Grantee:Leonardo Santana Novaes
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/15982-7 - Neuroplasticity in the basolateral complex of amygdala and on anxiety and extinction memory circuit mediated by glucocorticoids via GR
Grantee:Letícia Morais Bueno de Camargo
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 12/24002-0 - Effects of environmental enrichment in long-lasting anxiety symptoms triggered by acute stress: implications in the emotional memory acquisition
Grantee:Leonardo Santana Novaes
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/00908-9 - Stress-induced anxiety-like behaviors: glucocorticoid signaling in neuronal hyperexcitability and mitochondrial dysfunction within the basolateral amygdala complex
Grantee:Carolina Demarchi Munhoz
Support Opportunities: Regular Research Grants
FAPESP's process: 16/03572-3 - The relationship between glucocorticoid receptor activation and the neuronal hyperexcitability in the basolateral amygdala in the restraint stress-induced long-lasting anxiety and their implications in the impaired contextual fear extinction
Grantee:Carolina Demarchi Munhoz
Support Opportunities: Regular Research Grants