| Full text | |
| Author(s): |
Otuka, Adriano J. G.
[1]
;
Domeneguetti, Rafael R.
[2]
;
Moraes, Jonathas Q. R.
[1]
;
Balogh, Debora T.
[1]
;
Ribeiro, Sidney J. L.
[2]
;
Mendonca, Cleber R.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13560970 Sao Carlos, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Chem, BR-14800060 Araraquara, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | JOURNAL OF PHYSICS-PHOTONICS; v. 3, n. 2 APR 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Miniaturized environments have emerged as an excellent alternative to evaluate and understand biological mechanisms. These systems are able to simulate macroenvironments with high reproducibility, achieving many results in a short time of analysis. However, microenvironments require specific architectures that can be reached using laser micromachining techniques, such as two-photon polymerization (TPP). This technique has many advantages, allowing the production of environments without shape limitation and with special features. In this work, aided by the TPP technique, we produce different arrays of microstructures, fabricated using acrylate-based materials, in order to evaluate the growth and development of the Komagataeibacter xylinus bacteria, the micro-organism responsible for producing bacterial cellulose (BC), a natural polymer with several biological applications. BC grown in microenvironments presents similar features to those of biofilm formed in macroenvironments, maintaining their attractive properties. In addition, due to the high optical quality and mechanical resistance of the BC matrices, we use these films as flexible substrates in TPP experiments, obtaining promising results for tissue engineering studies. (AU) | |
| FAPESP's process: | 16/20094-8 - Fabrication of biocompatible and biologically active platforms using laser processing techniques |
| Grantee: | Adriano José Galvani Otuka |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/11283-7 - Nonlinear photonics: spectroscopy and advanced processing of materials |
| Grantee: | Cleber Renato Mendonça |
| Support Opportunities: | Research Projects - Thematic Grants |