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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Depression and anxiety disorders in patients with multiple sclerosis: association with neurodegeneration and neurofilaments

Full text
Author(s):
Tauil, C. B. [1] ; Rocha-Lima, A. D. [2] ; Ferrari, B. B. [2] ; Silva, F. M. [3] ; Machado, L. A. [3] ; Ramari, C. [1] ; Brandao, C. O. [2] ; dos Santos, L. M. B. [2] ; dos Santos-Neto, L. L. [1]
Total Authors: 9
Affiliation:
[1] Univ Brasilia, Dept Ciencias Med, Brasilia, DF - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Genet Evolucao Microbiol & Imunol, Unidade Neuroimunol, Campinas, SP - Brazil
[3] Hosp Base Brasilia, Dept Psicol, Brasilia, DF - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 54, n. 3 2021.
Web of Science Citations: 0
Abstract

There is increasing evidence that neurofilament light chain (NF-L) can be considered as a biomarker for neuro-axonal damage. This polypeptide can be released into the cerebrospinal fluid (CSF) and the blood, where it can be quantified. The concentration of NF-L is elevated in patients with multiple sclerosis (MS) and psychiatric disorders. We aimed to investigate the NF-L levels in the CSF from treated MS patients and the relationship with depression or anxiety. The study involved three groups: control group (individuals without inflammation), the relapse-remitting multiple sclerosis (RRMS)-untreated group, and the RRMS-Fingo group (RRMS patients who were treated with fingolimod). MS disability was assessed by the Expanded Disability Status Scale, and depression and anxiety were evaluated by a neuropsychologist, using the Hospital Anxiety and Depression Scale, the Beck Depression Inventory-II, and the Beck Anxiety Inventory. Individual CSF samples were collected to measure NF-L levels. The results of the statistical analysis on levels of NF-L in the CSF of control subjects, RRMS-untreated patients, and RRMS-Fingo patients were significant. The relationship between depression and anxiety in RRMS-Fingo patients and NF-L levels was not statistically significant. In conclusion, MS events such as anxiety and depression appear to contribute to the onset of clinical relapses, subclinical cases, and neurodegeneration. (AU)

FAPESP's process: 14/26431-0 - Multiple sclerosis, clinical study, neuropsychological, immunological, biomarkers and modifying-disease new drugs
Grantee:Leonilda Maria Barbosa dos Santos
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/17404-5 - Study of B lymphocytes subset in peripheral blood of patients with a primary progressive form of multiple sclerosis
Grantee:Leonilda Maria Barbosa dos Santos
Support Opportunities: Regular Research Grants