| Full text | |
| Author(s): Show less - |
Milani, Reinaldo R.
[1]
;
Alves, Osvaine J. A.
[1]
;
Bertanha, Camila S.
[1]
;
Gimenez, Valeria M. M.
[1]
;
Squarisi, Iara S.
[1]
;
Nicolella, Heloiza D.
[1]
;
Pagotti, Mariana C.
[1]
;
Tavares, Denise C.
[1]
;
e Silva, Marcio L. A.
[1]
;
Cunha, Wilson R.
[1]
;
Magalhaes, Lizandra G.
[1]
;
Januario, Ana H.
[1]
;
Pauletti, Patricia M.
[1]
Total Authors: 13
|
| Affiliation: | [1] Univ Franca, Nucleo Pesquisa Ciencias Exatas & Tecnol, BR-14404600 Franca, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | Química Nova; v. 43, n. 10, p. 1404-1407, DEC 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Fridericia speciosa (Bignoniaceae) is a liana that occurs in humid to dry vegetation in eastern and southeastern Brazil. Species belonging to the genus Fridericia are employed as medicinal plants. This study evaluates the antipromastigote and cytotoxic activities of the crude extract, fractions, and compounds isolated from F. speciosa, and an HPLC (High-Performance Liquid Chromatography) analytical method was used to quantify the bioactive flavonoids. The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated from the active EtOAc-soluble fraction (EAF) of the crude ethanol extract (LCE) obtained from F. speciosa leaves. Both LCE and EAF were active against the normal human lung fibroblast cell line GM07492A (IC50 of 460.7 µg mL-1 and 381.4 µg mL-1, respectively). Only EAF showed activity against Leishmania amazonensis (80.4% at 50 µg mL-1). Compounds 1 and 2 were quantified by HPLC-DAD in both LCE (1: 6.21%; 2: 1.11%) and EAF (1: 45.32%; 2: 2.00%). At 100 µM, compounds1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively, while their toxicities (IC50) to the normal cell were > 1000, 353.0, 766.2, and >1000 µg mL-1, respectively. Therefore, F. speciosa leaves are a prolific source of bioactive flavonoids. (AU) | |
| FAPESP's process: | 15/04999-8 - Chemical study of Fridericia speciosa Mart. (Bignoniaceae) and evaluation of lipoxygenase inhibitory activity and cytotoxicity |
| Grantee: | Reinaldo Rodrigues Milani |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 16/10313-4 - Phytochemistry study and evaluation of the schistosomicidal, cytotoxicity and leishmanicidal activities from cerrado plants |
| Grantee: | Patricia Mendonça Pauletti |
| Support Opportunities: | BIOTA-FAPESP Program - Regular Research Grants |
| FAPESP's process: | 13/09280-6 - Phytochemistry study and evaluation of the cytotoxicity and lipoxygenase inhibitory activity from Cerrado plants |
| Grantee: | Patricia Mendonça Pauletti |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/24860-0 - Acute toxicity evaluation of Stizophyllum perforatum leaves crude ethanol extract in vivo and chemical study associated with the evaluation of antiparasitic and cytotoxic activities in vitro |
| Grantee: | Osvaine Junior Alvarenga Alves |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |