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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anticancer Compounds Based on Isatin-Derivatives: Strategies to Ameliorate Selectivity and Efficiency

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Author(s):
Ferraz de Paiva, Raphael Enoque [1] ; Vieira, Eduardo Guimaraes [1] ; Rodrigues da Silva, Daniel [1] ; Wegermann, Camila Anchau [1, 2] ; Costa Ferreira, Ana Maria [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Sao Paulo - Brazil
[2] Univ Fed Fluminense, Niteroi, RJ - Brazil
Total Affiliations: 2
Document type: Review article
Source: FRONTIERS IN MOLECULAR BIOSCIENCES; v. 7, FEB 4 2021.
Web of Science Citations: 0
Abstract

In this review we compare and discuss results of compounds already reported as anticancer agents based on isatin-derivatives, metalated as well as non-metallated. Isatin compounds can be obtained from plants, marine animals, and is also found in human fluids as a metabolite of amino acids. Its derivatives include imines, hydrazones, thiosemicarbazones, among others, already focused on numerous anticancer studies. Some of them have entered in pre-clinical and clinical tests as antiangiogenic compounds or inhibitors of crucial proteins. As free ligands or coordinated to metal ions, such isatin derivatives showed promising antiproliferative properties against different cancer cells, targeting different biomolecules or organelles. Binding to metal ions usually improves its biological properties, indicating a modulation by the metal and by the ligand in a synergistic process. They also reveal diverse mechanisms of action, being able of binding DNA, generating reactive species that cause oxidative damage, and inhibiting selected proteins. Strategies used to improve the efficiency and selectivity of these compounds comprise structural modification of the ligands, metalation with different ions, syntheses of mononuclear and dinuclear species, and use of inserted or anchored compounds in selected drug delivery systems. (AU)

FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 16/16735-8 - Imobilization of potential metallopharmaceuticals in inorganic and organic matrices for modified delivery
Grantee:Eduardo Guimarães Vieira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/21537-6 - Polydentate imine ligands as modulators of copper reactivity in inflammation-related diseases and in bioorthogonal coupling reactions
Grantee:Raphael Enoque Ferraz de Paiva
Support Opportunities: Scholarships in Brazil - Post-Doctoral