Imobilization of potential metallopharmaceuticals in inorganic and organic matrices for modified delivery

• Grant number: 16/16735-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Effective date (Start): December 01, 2016
• Effective date (End): April 30, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Ana Maria da Costa Ferreira
• Grantee: Eduardo Guimarães Vieira
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID
• Associated scholarship(s): 17/21919-3 - Spectroscopic and magnetic characterization of metallo-pharmaceuticals immobilized in hybrid matrices for drug delivery, BE.EP.PD

Abstract

In this project we intend to develop hybrid compounds through the insertion or supporting of ligands and corresponding metal complexes, having biological activity already verified as antitumor, antioxidant or anti-inflammatory properties, in inorganic (as synthetic clays or mesoporous silica) or organic matrices (as dendrimers). The goal is to enhance its performance as potential pharmacological agents after being supported or inserted in the selected matrices. We intend to monitor an enhancement in its properties by monitoring its higher efficiency, higher stability, or higher selectivity after formation of corresponding hybrid materials. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERRAZ DE PAIVA, RAPHAEL ENOQUE; VIEIRA, EDUARDO GUIMARAES; RODRIGUES DA SILVA, DANIEL; WEGERMANN, CAMILA ANCHAU; COSTA FERREIRA, ANA MARIA. Anticancer Compounds Based on Isatin-Derivatives: Strategies to Ameliorate Selectivity and Efficiency. FRONTIERS IN MOLECULAR BIOSCIENCES, v. 7, FEB 4 2021. (13/07937-8, 16/16735-8, 18/21537-6)

DE AZEVEDO-FRANCA, JOSE ALEIXO; BARRIAS, EMILE; FRANCO, CHRIS HEBERT JESUS; VILLARREAL, WILMER; VIEIRA, EDUARDO GUIMARAES; DA COSTA FERREIRA, ANA MARIA; DE SOUZA, WANDERLEY; NAVARRO, MARIBEL. Promising fluconazole based zinc(II) and copper(II) coordination polymers against Chagas disease. Journal of Inorganic Biochemistry, v. 233, p. 12-pg., 2022-04-29. (16/16735-8, 13/07937-8)

VIEIRA, EDUARDO GUIMARAES; MIGUEL, RODRIGO BERNARDI; DA COSTA FERREIRA, ANA MARIA. Immobilization of [Cu(isapn)]ClO4 and [Zn(isapn)](ClO4)(2) complexes in a new silicon-based matrix and its antitumor activity. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 22, p. 1-pg., 2017-07-01. (13/07937-8, 16/16735-8)

DE AZEVEDO-FRANCA, JOSE ALEIXO; BORBA-SANTOS, LUANA PEREIRA; PIMENTEL, GIOVANA DE ALMEIDA; FRANCO, CHRIS HEBERT JESUS; SOUZA, CASSIANO; CELESTINO, JAQUELINE DE ALMEIDA; DE MENEZES, EMANUELLA FIGUEIREDO; DOS SANTOS, NATHALIA PINHEIRO; VIEIRA, EDUARDO GUIMARAES; FERREIRA, ANA MARIA DA COSTA; et al. Antifungal promising agents of zinc(II) and copper(II) derivatives based on azole drug. Journal of Inorganic Biochemistry, v. 219, JUN 2021. (16/16735-8, 13/07937-8)

COUTO, RICARDO ALEXANDRE ALVES; MIGUEL, RODRIGO BERNARDI; VIEIRA, EDUARDO GUIMARAES; BRENDLE, JOCELYNE; LIMOUSY, LIONEL; CONSTANTINO, VERA REGINA LEOPOLDO; FERREIRA, ANA MARIA DA COSTA. Synthetic beidellite clay as nanocarrier for delivery of antitumor oxindolimine-metal complexes. Journal of Inorganic Biochemistry, v. 240, p. 12-pg., 2022-12-28. (11/50318-1, 16/50317-9, 16/16735-8)

VIEIRA, EDUARDO GUIMARAES; MIGUEL, RODRIGO BERNARDI; DA SILVA, DANIEL RODRIGUES; FAZZI, RODRIGO BONI; ALVES DE COUTO, RICARDO ALEXANDRE; MARIN, JAYR HENRIQUE; ARRUDA TEMPERINI, MARCIA LAUDELINA; SHINOHARA, JORGE DA SILVA; TOMA, HENRIQUE EISI; RUSSO, LILIAN CRISTINA; et al. Functionalized nanoparticles as adjuvant to increase the cytotoxicity of metallodrugs toward tumor cells. NEW JOURNAL OF CHEMISTRY, v. 43, n. 1, p. 386-398, JAN 7 2019. (11/50318-1, 16/21070-5, 17/21919-3, 16/16735-8, 13/07937-8)

VIEIRA, EDUARDO GUIMARAES; FAZZI, RODRIGO BONI; MARTINS, DANIEL O. T. A.; SHEVELEVA, ALENA M.; TUNA, FLORIANA; FERREIRA, ANA MARIA DA COSTA. A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy. RSC ADVANCES, v. 13, n. 14, p. 5-pg., 2023-03-20. (17/21919-3, 16/16735-8, 13/07937-8, 16/50342-3)