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Imobilization of potential metallopharmaceuticals in inorganic and organic matrices for modified delivery

Grant number: 16/16735-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2016
Effective date (End): November 30, 2021
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal researcher:Ana Maria da Costa Ferreira
Grantee:Eduardo Guimarães Vieira
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID
Associated scholarship(s):17/21919-3 - Spectroscopic and magnetic characterization of metallo-pharmaceuticals immobilized in hybrid matrices for drug delivery, BE.EP.PD

Abstract

In this project we intend to develop hybrid compounds through the insertion or supporting of ligands and corresponding metal complexes, having biological activity already verified as antitumor, antioxidant or anti-inflammatory properties, in inorganic (as synthetic clays or mesoporous silica) or organic matrices (as dendrimers). The goal is to enhance its performance as potential pharmacological agents after being supported or inserted in the selected matrices. We intend to monitor an enhancement in its properties by monitoring its higher efficiency, higher stability, or higher selectivity after formation of corresponding hybrid materials. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE AZEVEDO-FRANCA, JOSE ALEIXO; BORBA-SANTOS, LUANA PEREIRA; PIMENTEL, GIOVANA DE ALMEIDA; FRANCO, CHRIS HEBERT JESUS; SOUZA, CASSIANO; CELESTINO, JAQUELINE DE ALMEIDA; DE MENEZES, EMANUELLA FIGUEIREDO; DOS SANTOS, NATHALIA PINHEIRO; VIEIRA, EDUARDO GUIMARAES; FERREIRA, ANA MARIA DA COSTA; DE SOUZA, WANDERLEY; ROZENTAL, SONIA; NAVARRO, MARIBEL. Antifungal promising agents of zinc(II) and copper(II) derivatives based on azole drug. Journal of Inorganic Biochemistry, v. 219, JUN 2021. Web of Science Citations: 2.
FERRAZ DE PAIVA, RAPHAEL ENOQUE; VIEIRA, EDUARDO GUIMARAES; RODRIGUES DA SILVA, DANIEL; WEGERMANN, CAMILA ANCHAU; COSTA FERREIRA, ANA MARIA. Anticancer Compounds Based on Isatin-Derivatives: Strategies to Ameliorate Selectivity and Efficiency. FRONTIERS IN MOLECULAR BIOSCIENCES, v. 7, FEB 4 2021. Web of Science Citations: 0.
VIEIRA, EDUARDO GUIMARAES; MIGUEL, RODRIGO BERNARDI; DA SILVA, DANIEL RODRIGUES; FAZZI, RODRIGO BONI; ALVES DE COUTO, RICARDO ALEXANDRE; MARIN, JAYR HENRIQUE; ARRUDA TEMPERINI, MARCIA LAUDELINA; SHINOHARA, JORGE DA SILVA; TOMA, HENRIQUE EISI; RUSSO, LILIAN CRISTINA; MAGALHAES, YULI THAMIRES; DIAS FILHO, NEWTON LUIZ; FORTI, FABIO LUIZ; DA COSTA FERREIRA, ANA MARIA. Functionalized nanoparticles as adjuvant to increase the cytotoxicity of metallodrugs toward tumor cells. NEW JOURNAL OF CHEMISTRY, v. 43, n. 1, p. 386-398, JAN 7 2019. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.