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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Breastfeeding importance and its therapeutic potential against SARS-CoV-2

Full text
Author(s):
da Costa, Aline Vasques [1] ; Goes, Carolina Purcell [1] ; Gama, Patricia [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: PHYSIOLOGICAL REPORTS; v. 9, n. 3 FEB 2021.
Web of Science Citations: 0
Abstract

During postnatal development, colostrum and breastmilk are sequentially the first sources of nutrition with protein components and bioactive molecules that confer protection and immunostimulatory function to the gut. Caseins, whey proteins, secretory immunoglobulin A (sIgA), mucins, tryptophan, and growth factors are among milk-borne elements that are directly important in the control of mucosa development and protection. Consequently, breastfeeding is associated with the low incidence of gastrointestinal inflammation and with the decrease in respiratory diseases during postnatal period. The novel coronavirus (SARS-CoV-2) binds to angiotensin II-converting enzyme (ACE2) on the cell membrane, allowing virus entrance, replication, and host commitment. ACE2 is expressed by different cell types, which include ciliated cells in the lungs and enterocytes in the intestine. Such cells are highly active in metabolism, as they internalize molecules to be processed and used by the organism. The disruption of ACE2 impairs leads to intestinal inflammation and decreased synthesis of serotonin, affecting motility. By reviewing the effects of SARS-CoV-2 in the gastrointestinal and respiratory tracts in infants, and gut responses to breastfeeding interruption, we suggest that it is important to maintain breastfeeding during SARS-CoV-2 infection, as it might be essential to protect newborns from gastrointestinal-associated disorders and relieve disease symptoms. (AU)

FAPESP's process: 20/02888-2 - Effects of early weaning on molecular markers during postnatal growth and development of intestinal
Grantee:Carolina Purcell Goes
Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
FAPESP's process: 18/07782-8 - Effects of early weaning on molecular markers during postnatal growth and development of intestinal mucosa in the rat.
Grantee:Patrícia Gama
Support Opportunities: Regular Research Grants
FAPESP's process: 18/07409-5 - Effect of early weaning on molecular markers and development of intestinal mucosa
Grantee:Aline Vasques da Costa
Support Opportunities: Scholarships in Brazil - Doctorate