Effect of maternal and paternal supplementation with antioxidant in pulmonary inflammatory process of the offspring of mice

• Grant number: 19/02679-7
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): May 01, 2019
• Effective date (End): May 05, 2022
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal researcher: Maria Notomi Sato
• Grantee: Ricardo Wesley Alberca Custódio
• Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Pregnancy is considered a period of increased susceptibility to infections due to the differential immunological conditions generated in fetal development. During pregnancy bacterial infections can lead to complications in the mother and the fetus, leading to early conceptions and abortion, being considered a serious maternal-child health and economic-social burden. Therefore, prophylactic and therapeutic interventions for infections that are not dangerous during pregnancy needs to be investigated. The maternal consumption of flavonoid naringenin during gestation does not show deleterious effects to the offspring and previous studies in the non-pregnant condition show an anti-inflammatory potential, in addition to its broad spectrum of action in metabolic syndromes. For this purpose, we will use a model of cervical and intrauterine inflammation induced by lipopolysaccharide during pregnancy of mice supplemented or not with naringenin (NAR). Additionally NAR supplementation, including breastfeeding, will investigate the effects of lung inflammatory response on offspring. Although most research focuses on the maternal importance on the immune system and health of offspring, recent researches has shown paternal influence. Among the mechanisms that may explain the paternal influence in the offspring are the MicroRNAs (miRNAs) of the semen. The miRNAS are small molecules of non-coding RNA, which regulate the expression of several genes and can be modified by dietary supplementation. Therefore, we will investigate the effect of maternal or paternal supplementation with NAR in the development of two clinically relevant respiratory syndromes during childhood: neutrophilic asthma and acute respiratory distress syndrome. The effect of maternal supplementation during pregnancy and/or breastfeeding on the development of both respiratory syndromes and the mechanisms responsible for the possible suppression of the inflammatory response will be evaluated. In parallel, we will analyze the effect of paternal NAR consumption prior to fertilization on the inflammatory response of the offspring and the changes in semen miRNAs. The present project is justified in understanding the effects of maternal and paternal supplementation on the development of inflammatory responses of the offspring, and may provide subsidies for the elaboration of prophylactic interventions.

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALBERCA, RICARDO WESLEY; GOMES, ELIANE; RUSSO, MOMTCHILO. CpG-ODN Signaling via Dendritic Cells-Expressing MyD88, but Not IL-10, Inhibits Allergic Sensitization. VACCINES, v. 9, n. 7 JUL 2021. Web of Science Citations: 0.

GOZZI-SILVA, SARAH CRISTINA; BENARD, GIL; ALBERCA, RICARDO WESLEY; YENDO, TATIANA MINA; EMIDIO TEIXEIRA, FRANCIANE MOURADIAN; OLIVEIRA, LUANA DE MENDONCA; BESERRA, DANIELLE ROSA; PIETROBON, ANNA JULIA; DE OLIVEIRA, EMILY ARAUJO; CALVIELLI CASTELO BRANCO, ANNA CLAUDIA; DE SOUZA ANDRADE, MILENA MARY; FERNANDES, IARA GRIGOLETTO; PEREIRA, NATALLI ZANETE; LEUZZI RAMOS, YASMIM ALEFE; LIMA, JULIA CATALDO; PROVENCI, BRUNA; MANGINI, SANDRIGO; DA SILVA DUARTE, ALBERTO JOSE; SATO, MARIA NOTOMI. SARS-CoV-2 Infection and CMV Dissemination in Transplant Recipients as a Treatment for Chagas Cardiomyopathy: A Case Report. TROPICAL MEDICINE AND INFECTIOUS DISEASE, v. 6, n. 1 MAR 2021. Web of Science Citations: 0.

ALBERCA, RICARDO WESLEY; LIMA, JULIA CATALDO; DE OLIVEIRA, EMILY ARAUJO; GOZZI-SILVA, SARAH CRISTINA; LEUZZI RAMOS, YASMIM ALEFE; DE SOUZA ANDRADE, MILENA MARY; BESERRA, DANIELLE ROSA; OLIVEIRA, LUANA DE MENDONCA; CALVIELLI CASTELO BRANCO, ANNA CLAUDIA; PIETROBON, ANNA JULIA; PEREIRA, NATALLI ZANETE; EMIDIO TEIXEIRA, FRANCIANE MOURADIAN; FERNANDES, IARA GRIGOLETTO; DA SILVA DUARTE, ALBERTO JOSE; BENARD, GIL; SATO, MARIA NOTOMI. COVID-19 Disease Course in Former Smokers, Smokers and COPD Patients. FRONTIERS IN PHYSIOLOGY, v. 11, JAN 27 2021. Web of Science Citations: 2.

ALBERCA, RICARDO WESLEY; DE SOUZA ANDRADE, MILENA MARY; CALVIELLI CASTELO BRANCO, ANNA CLAUDIA; PIETROBON, ANNA JULIA; PEREIRA, NATALLI ZANETE; FERNANDES, IARA GRIGOLETTO; OLIVEIRA, LUANA DE MENDONCA; EMIDIO TEIXEIRA, FRANCIANE MOURADIAN; BESERRA, DANIELLE ROSA; DE OLIVEIRA, EMILY ARAUJO; GOZZI-SILVA, SARAH CRISTINA; LEUZZI RAMOS, YASMIM ALEFE; DE BRITO, CYRO ALVES; ARNONE, MARCELO; ORFALI, RAQUEL LEAO; AOKI, VALERIA; DA SILVA DUARTE, ALBERTO JOSE; SATO, MARIA NOTOMI. Frequencies of CD33+CD11b+HLA-DR-CD14-CD66b+and CD33+CD11b+HLA-DR-CD14+CD66b-Cells in Peripheral Blood as Severity Immune Biomarkers in COVID-19. FRONTIERS IN MEDICINE, v. 7, OCT 14 2020. Web of Science Citations: 0.

ALBERCA, RICARDO WESLEY; TEIXEIRA, FRANCIANE MOURADIAN EMIDIO; BESERRA, DANIELLE ROSA; DE OLIVEIRA, EMILY ARAUJO; ANDRADE, MILENA MARY DE SOUZA; PIETROBON, ANNA JULIA; SATO, MARIA NOTOMI. Perspective: The Potential Effects of Naringenin in COVID-19. FRONTIERS IN IMMUNOLOGY, v. 11, SEP 25 2020. Web of Science Citations: 0.

ALBERCA, RICARDO WESLEY; PEREIRA, NATALLI ZANETE; OLIVEIRA, LUANDA MARA DA SILVA; GOZZI-SILVA, SARAH CRISTINA; SATO, MARIA NOTOMI. Pregnancy, Viral Infection, and COVID-19. FRONTIERS IN IMMUNOLOGY, v. 11, JUL 7 2020. Web of Science Citations: 3.

ALBERCA, RICARDO WESLEY; OLIVEIRA, LUANA DE MENDONCA; BRANCO, ANNA CLAUDIA CALVIELLI CASTELO; PEREIRA, NATALLI ZANETE; SATO, MARIA NOTOMI. Obesity as a risk factor for COVID-19: an overview. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, v. 61, n. 13 JUN 2020. Web of Science Citations: 26.