Platelet-Based Biomarkers for Diagnosis and Prognosis in COVID-19 Patients

Author(s):Show less -

Alberca, Ricardo Wesley ^{[1, 2]} ; Solis-Castro, Rosa Liliana ^[3] ; Solis-Castro, Maria Edith ^[4] ; Cardoso, Fernanda ^{[5, 1, 2]} ; Duarte, Alberto Jose da Silva ^{[1, 2]} ; Oliveira, Luana de Mendonca ^{[5, 1, 2]} ; Pereira, Natalli Zanete ^{[1, 2]} ; Gozzi-Silva, Sarah Cristina ^{[5, 1, 2]} ; de Oliveira, Emily Araujo ^{[5, 1, 2]} ; Aoki, Valeria ^{[1, 2]} ; Orfali, Raquel Leao ^{[1, 2]} ; Beserra, Danielle Rosa ^{[1, 2]} ; Andrade, Milena Mary de Souza ^{[1, 2]} ; Sato, Maria Notomi ^{[5, 1, 2]}

Affiliation

^[1] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunodeficiencies, LIM 56, BR-01246903 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Trop Med Sao Paulo, BR-01246903 Sao Paulo - Brazil

^[3] Univ Nacl Tumbes, Fac Ciencias Salud, Dept Acad Biol & Bioquim, Av Univ S-N, Tumbes 24000 - Peru

^[4] Univ Nacl Tumbes, Fac Ciencias Salud, Dept Acad Med Humana, Av Univ S-N, Tumbes 24000 - Peru

^[5] Univ Sao Paulo, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil

• Document type: Journal article
• Source: LIFE-BASEL; v. 11, n. 10 OCT 2021.
• Web of Science Citations: 0

Abstract

Coronavirus disease 2019 (COVID-19) caused millions of deaths worldwide. COVID-19's clinical manifestations range from no symptoms to a severe acute respiratory syndrome, which can result in multiple organ failure, sepsis, and death. Severe COVID-19 patients develop pulmonary and extrapulmonary infections, with a hypercoagulable state. Several inflammatory or coagulatory biomarkers are currently used with predictive values for COVID-19 severity and prognosis. In this manuscript, we investigate if a combination of coagulatory and inflammatory biomarkers could provide a better biomarker with predictive value for COVID-19 patients, being able to distinguish between patients that would develop a moderate or severe COVID-19 and predict the disease outcome. We investigated 306 patients with COVID-19, confirmed by severe acute respiratory syndrome coronavirus 2 RNA detected in the nasopharyngeal swab, and retrospectively analyzed the laboratory data from the first day of hospitalization. In our cohort, biomarkers such as neutrophil count and neutrophil-to-lymphocyte ratio from the day of hospitalization could predict if the patient would need to be transferred to the intensive care unit but failed to identify the patients \& PRIME; outcomes. The ratio between platelets and inflammatory markers such as creatinine, C-reactive protein, and urea levels is associated with patient outcomes. Finally, the platelet/neutrophil-to-lymphocyte ratio on the first day of hospitalization can be used with predictive value as a novel severity and lethality biomarker in COVID-19. These new biomarkers with predictive value could be used routinely to stratify the risk in COVID-19 patients since the first day of hospitalization.</p> (AU)

• FAPESP's process: 19/02679-7 - Effect of maternal and paternal supplementation with antioxidant in pulmonary inflammatory process of the offspring of mice
• Grantee: Ricardo Wesley Alberca Custódio
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 20/13148-0 - Evaluation of ATP-adenosine axis in lymphocytes in SARS-CoV-2 infection
• Grantee: Maria Notomi Sato
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/22448-0 - Analysis of natural killer memory cells and the antiviral response of CD8 + T cells in SARS-CoV-2 infection
• Grantee: Sarah Cristina Gozzi e Silva
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 17/18199-9 - Effect of maternal supplementation with retinoic acid during breastfeeding on the immune response of mice offspring
• Grantee: Maria Notomi Sato
• Support Opportunities: Regular Research Grants