| Full text | |
| Author(s): Show less - |
Alberca, Ricardo Wesley
[1, 2]
;
Solis-Castro, Rosa Liliana
[3]
;
Solis-Castro, Maria Edith
[4]
;
Cardoso, Fernanda
[5, 1, 2]
;
Duarte, Alberto Jose da Silva
[1, 2]
;
Oliveira, Luana de Mendonca
[5, 1, 2]
;
Pereira, Natalli Zanete
[1, 2]
;
Gozzi-Silva, Sarah Cristina
[5, 1, 2]
;
de Oliveira, Emily Araujo
[5, 1, 2]
;
Aoki, Valeria
[1, 2]
;
Orfali, Raquel Leao
[1, 2]
;
Beserra, Danielle Rosa
[1, 2]
;
Andrade, Milena Mary de Souza
[1, 2]
;
Sato, Maria Notomi
[5, 1, 2]
Total Authors: 14
|
| Affiliation: | [1] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunodeficiencies, LIM 56, BR-01246903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Trop Med Sao Paulo, BR-01246903 Sao Paulo - Brazil
[3] Univ Nacl Tumbes, Fac Ciencias Salud, Dept Acad Biol & Bioquim, Av Univ S-N, Tumbes 24000 - Peru
[4] Univ Nacl Tumbes, Fac Ciencias Salud, Dept Acad Med Humana, Av Univ S-N, Tumbes 24000 - Peru
[5] Univ Sao Paulo, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | LIFE-BASEL; v. 11, n. 10 OCT 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Coronavirus disease 2019 (COVID-19) caused millions of deaths worldwide. COVID-19's clinical manifestations range from no symptoms to a severe acute respiratory syndrome, which can result in multiple organ failure, sepsis, and death. Severe COVID-19 patients develop pulmonary and extrapulmonary infections, with a hypercoagulable state. Several inflammatory or coagulatory biomarkers are currently used with predictive values for COVID-19 severity and prognosis. In this manuscript, we investigate if a combination of coagulatory and inflammatory biomarkers could provide a better biomarker with predictive value for COVID-19 patients, being able to distinguish between patients that would develop a moderate or severe COVID-19 and predict the disease outcome. We investigated 306 patients with COVID-19, confirmed by severe acute respiratory syndrome coronavirus 2 RNA detected in the nasopharyngeal swab, and retrospectively analyzed the laboratory data from the first day of hospitalization. In our cohort, biomarkers such as neutrophil count and neutrophil-to-lymphocyte ratio from the day of hospitalization could predict if the patient would need to be transferred to the intensive care unit but failed to identify the patients \& PRIME; outcomes. The ratio between platelets and inflammatory markers such as creatinine, C-reactive protein, and urea levels is associated with patient outcomes. Finally, the platelet/neutrophil-to-lymphocyte ratio on the first day of hospitalization can be used with predictive value as a novel severity and lethality biomarker in COVID-19. These new biomarkers with predictive value could be used routinely to stratify the risk in COVID-19 patients since the first day of hospitalization.</p> (AU) | |
| FAPESP's process: | 19/02679-7 - Effect of maternal and paternal supplementation with antioxidant in pulmonary inflammatory process of the offspring of mice |
| Grantee: | Ricardo Wesley Alberca Custódio |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 20/13148-0 - Evaluation of ATP-adenosine axis in lymphocytes in SARS-CoV-2 infection |
| Grantee: | Maria Notomi Sato |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/22448-0 - Analysis of natural killer memory cells and the antiviral response of CD8 + T cells in SARS-CoV-2 infection |
| Grantee: | Sarah Cristina Gozzi e Silva |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 17/18199-9 - Effect of maternal supplementation with retinoic acid during breastfeeding on the immune response of mice offspring |
| Grantee: | Maria Notomi Sato |
| Support Opportunities: | Regular Research Grants |