Unilateral diaphragmatic paralysis: inspiratory muscles, breathlessness and exercise capacity

Author(s):Show less -

Pereira, Mayra Caleffi ^[1] ; Cardenas, Leticia Z. ^{[2, 1]} ; Ferreira, Jeferson G. ^{[2, 1]} ; Iamonti, Vinicius C. ^[1] ; Santana, Pauliane Vieira ^{[2, 1]} ; Apanavicius, Andre ^[1] ; Caruso, Pedro ^{[2, 1]} ; Fernandez, Angelo ^[3] ; de Carvalho, Carlos R. R. ^[1] ; Langer, Daniel ^{[4, 5]} ; de Albuquerque, Andre L. P. ^{[6, 1]}

Affiliation

^[1] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Pulm Div, Heart Inst InCor, Sao Paulo - Brazil

^[2] AC Camargo Canc Ctr, Intens Care Unit, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Thorac Surg Div, InCor, Sao Paulo - Brazil

^[4] Univ Leuven, KU Leuven, Res Grp Cardiovasc & Resp Rehabil, Fac Kinesiol & Rehabil Sci, Dept Rehabil Sci, Leuven - Belgium

^[5] Univ Hosp Leuven, Resp Rehabil & Resp Div, Leuven - Belgium

^[6] Sirio Libanes Teaching & Res Inst, Sao Paulo - Brazil

• Document type: Journal article
• Source: ERJ OPEN RESEARCH; v. 7, n. 1 JAN 1 2021.
• Web of Science Citations: 0

Abstract

Background: Patients with unilateral diaphragmatic paralysis (UDP) may present with dyspnoea without specific cause and limited ability to exercise. We aimed to investigate the diaphragm contraction mechanisms and nondiaphragmatic inspiratory muscle activation during exercise in patients with UDP, compared with healthy individuals. Methods: Pulmonary function, as well as volitional and nonvolitional inspiratory muscle strength were evaluated in 35 patients and in 20 healthy subjects. Respiratory pressures and electromyography of scalene and sternocleidomastoid muscles were continuously recorded during incremental maximal cardiopulmonary exercise testing until symptom limitation. Dyspnoea was assessed at rest, every 2 min during exercise and at the end of exercise with a modified Borg scale. Main results: Inspiratory muscle strength measurements were significantly lower for patients in comparison to controls (all p<0.05). Patients achieved lower peak of exercise (lower oxygen consumption) compared to controls, with both gastric (-9.8 +/- 4.6 cmH(2)O versus 8.9 +/- 6.0 cmH(2)O) and transdiaphragmatic (6.5 +/- 5.5 cmH(2)O versus 26.9 +/- 10.9 cmH(2)O) pressures significantly lower, along with larger activation of both scalene (40 +/- 22% EMGmax versus 18 +/- 14% EMGmax) and sternocleidomastoid (34 +/- 22% EMGmax versus 14 +/- 8% EMGmax). In addition, the paralysis group presented significant differences in breathing pattern during exercise (lower tidal volume and higher respiratory rate) with more dyspnoea symptoms compared to the control group. Conclusion: The paralysis group presented with exercise limitation accompanied by impairment in transdiaphragmatic pressure generation and larger accessory inspiratory muscles activation compared to controls, thereby contributing to a neuromechanical dissociation and increased dyspnoea perception. (AU)