Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New sol-gel-derived magnetic bioactive glass-ceramics containing superparamagnetic hematite nanocrystals for hyperthermia application

Full text
Author(s):
Borges, Roger [1] ; Mendonca-Ferreira, Leticie [1] ; Rettori, Carlos [1, 2] ; Pereira, Isis S. O. [1] ; Baino, Francesco [3] ; Marchi, Juliana [1]
Total Authors: 6
Affiliation:
[1] Univ Fed ABC, Ctr Ciencias Nat & Humans, Ave Estados 5001 Bangu, BR-08210180 Santo Andre, SP - Brazil
[2] Univ Estadual Campinas, Inst Fis Gleb Wataghin, Rua Sergio Buarque Holanda 777 Cidade Univ, BR-13083859 Campinas, SP - Brazil
[3] Politecn Torino, Dept Appl Sci & Technol, Corso Duca Abruzzi 24, I-10129 Turin - Italy
Total Affiliations: 3
Document type: Journal article
Source: Materials Science & Engineering C-Materials for Biological Applications; v. 120, JAN 2021.
Web of Science Citations: 0
Abstract

Although the three main phases of iron oxide - hematite, maghemite, and magnetite - exhibit superparamagnetic properties at the nanoscale, only maghemite and magnetite phases have been explored in magnetic bioactive glass-ceramics aimed at applications in cancer treatment by hyperthermia. In this work, it is reported for the first time the superparamagnetic properties of hematite nanocrystals grown in a 58S bioactive glass matrix derived from sol-gel synthesis. The glass-ceramics are based on the (100-x)(58SiO(2)-33CaO-9P(2)O(5))-xFe(2)O(3) system (x = 10, 20 and 30 wt%). A thermal treatment leads to the growth of hematite (alpha-Fe2O3) nanocrystals, conferring superparamagnetic properties to the glass-ceramics, which is enough to produce heat under an external alternating magnetic field. Besides, the crystallization does not inhibit materials bioactivity, evidenced by the formation of calcium phosphate onto the glass-ceramic surface upon soaking in simulated body fluid. Moreover, their cytotoxicity is similar to other magnetic bioactive glass-ceramics reported in the literature. Finally, these results suggest that hematite nanocrystals' superparamagnetic properties may be explored in multifunctional glass-ceramics applied in bone cancer treatment by hyperthermia allied to bone regeneration. (AU)

FAPESP's process: 16/16512-9 - Development of a hydrogel-based delivery system for release of biocompatible glasses ions and drug as support in treatment of bone cancer and subsequent bone regeneration
Grantee:Juliana Marchi
Support type: Regular Research Grants