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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Targeting implant-associated infections: titanium surface loaded with antimicrobial

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Author(s):
Silva Souza, Joao Gabriel [1, 2, 3] ; Bertolini, Martinna Mendonca [4] ; Costa, Raphael Cavalcante [1] ; Nagay, Bruna Egumi [1] ; Dongari-Bagtzoglou, Anna [4] ; Ricardo Barao, Valentim Adelino [1]
Total Authors: 6
Affiliation:
[1] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Prosthodont & Periodontol, BR-13414903 Piracicaba, SP - Brazil
[2] Univ Guarulhos, Dent Res Div, BR-07023070 Guarulhos, SP - Brazil
[3] Dent Sci Sch, Fac Ciencias Odontol FCO, BR-39401303 Montes Claros, MG - Brazil
[4] Univ Connecticut, Hlth Ctr, Dept Oral Hlth & Diagnost Sci, Farmington, CT 06030 - USA
Total Affiliations: 4
Document type: Review article
Source: ISCIENCE; v. 24, n. 1 JAN 22 2021.
Web of Science Citations: 0
Abstract

Implant devices have = proven a successful treatment modality in reconstructive surgeries. However, increasing rates of peri-implant diseases demand further examination of their pathogenesis. Polymicrobial biofilm formation on titanium surfaces has been considered the main risk factor for inflammatory processes on tissues surrounding implant devices, which often lead to implant failure. To overcome microbial accumulation on titanium surfaces biofilm targeting strategies have been developed to modify the surface and incorporate antimicrobial coatings. Because antibiotics are widely used to treat polymicrobial infections, these agents have recently started to be incorporated on titanium surface. This review discusses the biofilm formation on titanium dental implants and key factors to be considered in therapeutic and preventative strategies. Moreover, a systematic review was conducted on coatings developed for titanium surfaces using different antibiotics. This review will also shed light on potential alternative strategies aiming to reduce microbial loads and control polymicrobial infection on implanted devices. (AU)

FAPESP's process: 20/05231-4 - Development of a new thermosensitive hydrogel for controlled release of drugs to prevent and treat peri-implant inflammations
Grantee:Valentim Adelino Ricardo Barão
Support Opportunities: Regular Research Grants