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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Transcranial low-level laser therapy in an in vivo model of stroke: Relevance to the brain infarct, microglia activation and neuroinflammation

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Vogel, Debora D. S. [1] ; Ortiz-Villatoro, Nancy N. [1] ; Araujo, Noemi S. [1] ; Marques, Marcia Jonathas Guimaraes [1] ; Aimbire, Flavio [2] ; Scorza, Fulvio A. [1] ; Scorza, Carla A. [1] ; Albertini, Regiane [3]
Total Authors: 8
[1] Univ Fed Sao Paulo UNIFESP, Escola Paulista Med EPM, Dept Neurol & Neurocirurg, Disciplina Neurociencia, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Ciencia & Tecnol, Programa Posgrad Med Translac, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Ciencia & Tecnol, Programa Posgrad Ciencia Movimento Humano & Reabi, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Biophotonics; v. 14, n. 6 MAR 2021.
Web of Science Citations: 3

Stroke is the main cause of death and functional disability. The available therapy affects only 5% of patients, and new therapeutic approaches have been constantly tested. Transcranial photobiomodulation (PBM) is promising for its neuroprotective effect on brain injuries. Thus, the present study investigated the PBM effects in an in vivo model of ischemic stroke induced by photothrombosis (PT). Five different groups of Wistar rats were submitted or not to a daily dose of fish oil or/and laser sessions for 2 months. The ischemia volume was evaluated by stereology; GFAP, Iba and NeuN by immunohistochemistry; TNF-alpha, IL-1 beta, IL-6, IL-10 and TGF-beta by ELISA assay. PBM influenced both the lesion volume and the GFAP. Furthermore, PBM and omega-3 or both reduced Iba RNAm. PBM reduced TNF-alpha, IL-1 beta, IL-6, brain damage, neuroinflammation and microglial activation, and it increased astroglial activity in peri-lesioned region after stroke. (AU)

FAPESP's process: 16/10286-7 - Supplementation Paper Assessment with Omega -3 and laser therapy of low intensity in the Thalamus in Experimental Model of Ischemic Stroke
Grantee:Regiane Albertini de Carvalho
Support type: Regular Research Grants