The Role of Anaphase-Promoting Complex/Cyclosome (APC/C) in Plant Reproduction

Author(s)

Saleme, Marina de Lyra Soriano ^[1] ; Andrade, Ingrid Rocha ^[1] ; Eloy, Nubia Barbosa ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Biol Sci, Escola Super Agr Luiz de Queiroz, Piracicaba - Brazil

• Document type: Review article
• Source: FRONTIERS IN PLANT SCIENCE; v. 12, FEB 24 2021.
• Web of Science Citations: 3

Abstract

Most eukaryotic species propagate through sexual reproduction that requires male and female gametes. In flowering plants, it starts through a single round of DNA replication (S phase) and two consecutive chromosome segregation (meiosis I and II). Subsequently, haploid mitotic divisions occur, which results in a male gametophyte (pollen grain) and a female gametophyte (embryo sac) formation. In order to obtain viable gametophytes, accurate chromosome segregation is crucial to ensure ploidy stability. A precise gametogenesis progression is tightly regulated in plants and is controlled by multiple mechanisms to guarantee a correct evolution through meiotic cell division and sexual differentiation. In the past years, research in the field has shown an important role of the conserved E3-ubiquitin ligase complex, Anaphase-Promoting Complex/Cyclosome (APC/C), in this process. The APC/C is a multi-subunit complex that targets proteins for degradation via proteasome 26S. The functional characterization of APC/C subunits in Arabidopsis, which is one of the main E3 ubiquitin ligase that controls cell cycle, has revealed that all subunits investigated so far are essential for gametophytic development and/or embryogenesis. (AU)

• FAPESP's process: 20/00888-5 - APC as an entry point to study small molecule regulation of the cell cycle
• Grantee: Marina de Lyra Soriano Saleme
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 20/02353-1 - Use of anaphase promoter complex genes to increase biomass
• Grantee: Ingrid Andrade Rocha
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 17/10333-8 - APC as an entry point to study small molecule regulation of the cell cycle
• Grantee: Nubia Barbosa Eloy
• Support Opportunities: Research Grants - Young Investigators Grants