Adults With Unilateral Cleft Lip and Palate Present Reduced Internal Nasal Volumes: Findings of a Three-Dimensional Morphometric Assessment in Cone-Beam Computed Tomography Scans

Author(s)

Mettelziefen dos Inocentes, Renan Jhordan ^[1] ; Marzano-Rodrigues, Maria Noel ^[1] ; de Espindola, Guilherme Goncalves ^[2] ; Garcia-Uso, Michele ^[1] ; Yatabe-Ioshida, Marilia Sayako ^[3] ; Kiemle Trindade, Inge Elly ^{[2, 1]} ; Trindade-Suedam, Ivy Kiemle ^{[2, 1]}

Affiliation

^[1] Univ Sao Paulo, Hosp Rehabil Craniofacial Anomalies HRAC, Lab Physiol, Sleep Unit, Funct Imaging Unit, Bauru, SP - Brazil

^[2] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP - Brazil

^[3] Univ Michigan, Dept Orthodont & Pediat Dent, Ann Arbor, MI 48109 - USA

• Document type: Journal article
• Source: JOURNAL OF CRANIOFACIAL SURGERY; v. 32, n. 1, p. E15-E19, JAN-FEB 2021.
• Web of Science Citations: 0

Abstract

The main purpose was to assess and compare nasal cavity (NC) volumes among adults with unilateral (UCLP) and bilateral cleft lip and palate (BCLP) and in noncleft controls (CON), by means of cone-beam computed tomography (CBCT) three-dimensional reconstructions. Forty-five scans of individuals with class III skeletal pattern, matched by age, were gathered in 3 groups: UCLP (n = 15), BCLP (n = 15) and (CON) (n = 15). The NC volume was assessed three-dimensionally, using Dolphin 11.8 software. Descriptive normally distributed data was presented as mean (+/- SD). Comparisons of NC volume among groups was performed using ANOVA test (P < 0.05). The NC mean volumes corresponded to 14.7(+/- 2.2) cm(3) (UCLP), 17.1(+/- 2.2) cm(3) (BCLP) and 18.1(+/- 3.8) cm(3) (CON), respectively. UCLP individuals presented a significantly reduced NC volume when compared to controls (P = 0.006). No differences were observed between UCLP versus BCLP or BCLP versus CON. The intraclass correlation coefficient suggested a high intra- and inter-examiners agreement (>.075). Individuals with unilateral cleft lip and palate presented reduced NC when compared to individuals without cleft lip and palate. CBCT scans can be considered a highly accurate tool for morphometric assessments of craniofacial structures. (AU)

• FAPESP's process: 15/20906-0 - Tomographic 3D analysis of the nasal cavity of adults with unilateral and bilateral cleft lip and palate
• Grantee: Renan Jhordan Mettelziefen dos Inocentes
• Support Opportunities: Scholarships in Brazil - Scientific Initiation