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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multidisciplinary rehabilitation program: effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia

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Author(s):
Glenda Dias Santos [1] ; Paula Villela Nunes [2] ; Florindo Stella ; Paula Schimidt Brum [4] ; Monica Sanches Yassuda ; Linda Massako Ueno [6] ; Wagner Farid Gattaz [7] ; Orestes Vicente Forlenza [8]
Total Authors: 8
Affiliation:
[1] University of São Paulo. Faculty of Medicine. Department and Institute of Psychiatry - Brasil
[2] University of São Paulo. Faculty of Medicine. Department and Institute of Psychiatry - Brasil
[4] University of São Paulo. Faculty of Medicine. Department of Neurology - Brasil
[6] University of São Paulo. School of Arts, Sciences and Humanities - Brasil
[7] University of São Paulo. Faculty of Medicine. Department and Institute of Psychiatry - Brasil
[8] University of São Paulo. Faculty of Medicine. Department and Institute of Psychiatry - Brasil
Total Affiliations: 8
Document type: Journal article
Source: ARCHIVES OF CLINICAL PSYCHIATRY; v. 42, n. 6, p. 153-156, 2015-12-00.
Abstract

Abstract Background Non-pharmalogical interventions represent an important complement to standard pharmalogical treatment in dementia. Objective This study aims to evaluate the effects of a multidisciplinary rehabilitation program on cognitive ability, quality of life and depression symptoms in patients with Alzheimer’s disease (AD) and cognitive impairment without dementia (CIND). Methods Ninety-seven older adults were recruited to the present study. Of these, 70 patients had mild AD and were allocated into experimental (n = 54) or control (n = 16) groups. Two additional active comparison groups were constituted with patients with moderate AD (n = 13) or with CIND (n = 14) who also received the intervention. The multidisciplinary rehabilitation program lasted for 12 weeks and was composed by sessions of memory training, recreational activities, verbal expression and writing, physical therapy and physical training, delivered in two weekly 6-hour sessions. Results As compared to controls, mild AD patients who received the intervention had improvements in cognition (p = 0.021) and quality of life (p = 0.003), along with a reduction in depressive symptoms (p < 0.001). As compared to baseline, CIND patients displayed at the end of the intervention improvements in cognition (p = 0.005) and depressive symptoms (p = 0.011). No such benefits were found among patients with moderate AD.Discussion: This multidisciplinary rehabilitation program was beneficial for patients with mild AD and CIND. However, patients with moderate dementia did not benefit from the intervention. (AU)

FAPESP's process: 09/52825-8 - Neurobiology of Alzheimer's disease: risk markers, prognosis and therapeutic response
Grantee:Wagner Farid Gattaz
Support Opportunities: Research Projects - Thematic Grants