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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Probing axial metal distribution on biopolymer-based layer-by-layer films for antimicrobial use

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Taketa, Thiago B. [1] ; Bataglioli, Rogerio A. [1] ; Rocha Neto, Joao Batista M. [1] ; Beppu, Marisa M. [1]
Total Authors: 4
[1] Univ Estadual Campinas, Sch Chem Engn, 500 Albert Einstein Av, BR-13083852 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Web of Science Citations: 0

This study presents the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications. Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C-60(+) cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy. Despite the use of the layer-by-layer approach for film assembly, these PEM films present a nonstratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction. Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity. The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior. (AU)

FAPESP's process: 16/10193-9 - New mechanisms for controlling triggered release of anticancer drugs in cellular backpacks
Grantee:Rogério Aparecido Bataglioli
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 18/20560-4 - Development of bioactive materials based on proteins and natural polymers aiming applications of biomedical interest.
Grantee:Marisa Masumi Beppu
Support type: Regular Research Grants