| Full text | |
| Author(s): Show less - |
Naslavsky, Michel Satya
[1]
;
Vidigal, Mateus
[1]
;
Barros Matos, Larissa do Rego
[1]
;
Coria, Vivian Romanholi
[1]
;
Batista Junior, Pedro Benedito
[2]
;
Razuk, Alvaro
[2]
;
Nascimento Saldiva, Paulo Hilario
[3]
;
Dolhnikoff, Marisa
[3]
;
Schidlowski, Laire
[4]
;
Prando, Carolina
[4]
;
Cunha-Neto, Edecio
[5]
;
Condino-Neto, Antonio
[6]
;
Passos-Bueno, Maria Rita
[1]
;
Zatz, Mayana
[1]
Total Authors: 14
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biociencias, Dept Genet & Biol Evolut, Ctr Pesquisa Genoma Humano & Celulas Tronco, BR-05508090 Sao Paulo, SP - Brazil
[2] Inst Prevent Senior, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo FMUSP, Dept Patol, Fac Med, Sao Paulo, SP - Brazil
[4] Hosp Pequeno Principe, Fac Pequeno Principe, Inst Pesquisa Pele Pequeno Principe, Curitiba, Parana - Brazil
[5] Univ Sao Paulo, Inst Coracao, Hosp Clin, Fac Med, Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Inst Ciencias Biomed, Lab Oratorio Imunol Humana, Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Review article |
| Source: | GENETICS AND MOLECULAR BIOLOGY; v. 44, n. 1, 1 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
COVID-19 comprises clinical outcomes of SARS-CoV-2 infection and is highly heterogeneous, ranging from asymptomatic individuals to deceased young adults without comorbidities. There is growing evidence that host genetics play an important role in COVID-19 severity, including inborn errors of immunity, age-related inflammation and immunosenescence. Here we present a brief review on the known order of events from infection to severe system-wide disturbance due to COVID-19 and summarize potential candidate genes and pathways. Finally, we propose a strategy of subject's ascertainment based on phenotypic extremes to take part in genomic studies and elucidate intrinsic risk factors involved in COVID-19 severe outcomes. (AU) | |
| FAPESP's process: | 13/08028-1 - CEGH-CEL - Human Genome and Stem Cell Research Center |
| Grantee: | Mayana Zatz |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 14/50931-3 - Aging and genetic disorders: genomics and metagenomics |
| Grantee: | Mayana Zatz |
| Support Opportunities: | Research Projects - Thematic Grants |