Clinical Application of Human Induced Pluripotent Stem Cell-Derived Organoids as an Alternative to Organ Transplantation

Author(s)

Ping Hsia, Gabriella Shih ^[1] ; Esposito, Joyce ^[1] ; da Rocha, Leticia Alves ^{[1, 2]} ; Guimaraes Ramos, Sofia Ligia ^[1] ; Okamoto, Oswaldo Keith ^{[1, 3]}

Affiliation

^[1] Univ Sao Paulo, Human Genome & Stem Cell Res Ctr, Inst Biociencias, Dept Genet & Biol Evolut, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Hosp Clin, Fac Med, Inst Crianca, Sao Paulo, SP - Brazil

^[3] Hosp Israelita Albert Einstein, Hemotherapy & Cell Therapy Dept, Sao Paulo, SP - Brazil

• Document type: Review article
• Source: STEM CELLS INTERNATIONAL; v. 2021, FEB 24 2021.
• Web of Science Citations: 0

Abstract

Transplantation is essential and crucial for individuals suffering from end-stage organ failure diseases. However, there are still many challenges regarding these procedures, such as high rates of organ rejection, shortage of organ donors, and long waiting lines. Thus, investments and efforts to develop laboratory-grown organs have increased over the past years, and with the recent progress in regenerative medicine, growing organs in vitro might be a reality within the next decades. One of the many different strategies to address this issue relies on organoid technology, a miniaturized and simplified version of an organ. Here, we address recent progress on organoid research, focusing on transplantation of intestine, retina, kidney, liver, pancreas, brain, lung, and heart organoids. Also, we discuss the main outcomes after organoid transplantation, common challenges faced by these promising regenerative medicine approaches, and future perspectives on the field. (AU)

• FAPESP's process: 14/50931-3 - Aging and genetic disorders: genomics and metagenomics
• Grantee: Mayana Zatz
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 13/08028-1 - CEGH-CEL - Human Genome and Stem Cell Research Center
• Grantee: Mayana Zatz
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC