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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A double edged-sword - The Complement System during SARS-CoV-2 infection

Full text
Author(s):
Santiesteban-Lores, Lazara Elena [1] ; Amamura, Thais Akemi [1] ; da Silva, Tiago Francisco [1] ; Midon, Leonardo Moura [1] ; Carneiro, Milena Carvalho [1] ; Isaac, Lourdes [1] ; Bavia, Lorena [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Av Prof Lineu Prestes 1730, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: Life Sciences; v. 272, MAY 1 2021.
Web of Science Citations: 0
Abstract

In the past 20 years, infections caused by coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2 have posed a threat to public health since they may cause severe acute respiratory syndrome (SARS) in humans. The Complement System is activated during viral infection, being a central protagonist of innate and acquired immunity. Here, we report some interactions between these three coronaviruses and the Complement System, highlighting the central role of C3 with the severity of these infections. Although it can be protective, its role during coronavirus infections seems to be contradictory. For example, during SARS-CoV-2 infection, Complement System can control the viral infection in asymptomatic or mild cases; however, it can also intensify local and systemic damage in some of severe COVID-19 patients, due to its potent proinflammatory effect. In this last condition, the activation of the Complement System also amplifies the cytokine storm and the pathogenicity of coronavirus infection. Experimental treatment with Complement inhibitors has been an enthusiastic field of intense investigation in search of a promising additional therapy in severe COVID-19 patients. (AU)

FAPESP's process: 19/19800-3 - Training in microbiology and immunology techniques
Grantee:Milena Carvalho Carneiro
Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
FAPESP's process: 17/10208-9 - Evaluation of the proteolytic activity of proteases secreted by pathogenic leptospires in phagocytosis by human and murine phagocytes
Grantee:Thais Akemi Amamura
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/12924-3 - Etiopathogenesis of Leptospirosis: contribution of the complement system for the control of infection in vivo and in vitro and inflammatory response: identification of gene polymorphisms of the complement system in Leptospirosis patients
Grantee:Lourdes Isaac
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/26574-7 - Complement system and Leptospirosis: understanding the role of C3 in renal fibrosis induced by chronic infection of pathogenic leptospires in murine experimental model
Grantee:Leonardo Moura Midon
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 19/01435-7 - Evaluation of leptospira phagocytosis by peritoneal macrophages from C3 deficient mice
Grantee:Tiago Francisco da Silva
Support Opportunities: Scholarships in Brazil - Master