The bile acid TUDCA and neurodegenerative disorders: An overview

Author(s)

Zangerolamo, Lucas ^[1] ; Vettorazzi, Jean F. ^[2] ; Rosa, Lucas R. O. ^[1] ; Carneiro, Everardo M. ^[1] ; Barbosa, Helena C. L. ^[1]

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Dept Struct & Funct Biol, Obes & Comorbid Res Ctr, Campinas, SP - Brazil

^[2] UNIVEL, Educ Union Cascavel, Cascavel, Parana - Brazil

• Document type: Review article
• Source: Life Sciences; v. 272, MAY 1 2021.
• Web of Science Citations: 0

Abstract

Bear bile has been used in Traditional Chinese Medicine for thousands of years due to its therapeutic potential and clinical applications. The tauroursodeoxycholic acid (TUDCA), one of the acids found in bear bile, is a hydrophilic bile acid and naturally produced in the liver by conjugation of taurine to ursodeoxycholic acid (UDCA). Several studies have shown that TUDCA has neuroprotective action in several models of neurodegenerative disorders (ND), including Alzheimer's disease, Parkinson's disease, and Huntington's disease, based on its potent ability to inhibit apoptosis, attenuate oxidative stress, and reduce endoplasmic reticulum stress in different experimental models of these illnesses. Our research extends the knowledge of the bile acid TUDCA actions in ND and the mechanisms and pathways involved in its cytoprotective effects on the brain, providing a novel perspective and opportunities for treatment of these diseases. (AU)

• FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
• Grantee: Licio Augusto Velloso
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 18/06363-1 - Therapeutic potential of GHRH and metformin on pancreatic beta cell function against endoplasmic reticulum stress and type 2 diabetes mellitus progress
• Grantee: Helena Cristina de Lima Barbosa
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/23729-1 - Molecular mechanisms of the ARHGAP21 RhoGAP in the VLDL vesicles formation in hepatocytes of ARHGAP21-heterozygous C57BL/6 mice
• Grantee: Lucas Zangerolamo
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 18/20213-2 - Role of TUDCA bile acid in the glycemic and energetic metabolism of mice with Alzheimer's and senile
• Grantee: Lucas Zangerolamo
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 15/12611-0 - Molecular mechanisms involved in pancreatic beta cell disfunction and dead in diabetes mellitus: strategies for the inhibition of these processes and restoration of the insular mass
• Grantee: Antonio Carlos Boschiero
• Support Opportunities: Research Projects - Thematic Grants