| Full text | |
| Author(s): |
Total Authors: 2
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| Affiliation: | [1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Biosci, Campinas - Brazil
Total Affiliations: 1
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| Document type: | Journal article |
| Source: | Journal of Molecular Evolution; v. 89, n. 4-5 MAR 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Proteins can evolve by accumulating changes on amino acid sequences. These changes are mainly caused by missense mutations on its DNA coding sequences. Mutations with neutral or positive effects on fitness can be maintained while deleterious mutations tend to be eliminated by natural selection. Amino acid changes are influenced by the biophysical, chemical, and biological properties of amino acids. There is a multiplicity of amino acid properties that can influence the function and expression of proteins. Amino acid properties can be expressed into numerical indexes, which can help to predict functional and structural aspects of proteins and allow statistical inferences of selection pressure on amino acid usage. The accuracy of these analyses may be compromised by the existence of several numerical indexes that measure the same amino acid property, and the lack of objective parameters to determine the most accurate and biologically relevant index. In the present study, the gradient consistency test was used in order to estimate the magnitude of directional selection imparted by amino acid biochemical and biophysical properties on protein evolution. (AU) | |
| FAPESP's process: | 18/23038-7 - Development of softwares for images optimization of the tooth enamel microstructure in whole teeth and fingerprints obtained from distance |
| Grantee: | Giovani Bressan Fogalli |
| Support Opportunities: | Scholarships in Brazil - Doctorate |