| Full text | |
| Author(s): |
Kato, Melissa Thiemi
[1]
;
Hannas, Angelica Reis
[2]
;
Cardoso, Cristiane de Almeida Baldini
[3]
;
Cassiano, Luiza de Paula Silva
[4]
;
Naves, Paula Andery
[3]
;
Magalhaes, Ana Carolina
[2]
;
Tjaderhane, Leo
[5, 6, 7]
;
Buzalaf, Marilia Afonso Rabelo
[2]
Total Authors: 8
|
| Affiliation: | [1] Univ Ctr Oeste Paulista FACOPH, Dept Dent, 72 Luiz Gimenez Mocegose, Piratininga, SP - Brazil
[2] Univ Sao Paulo, Bauru Sch Dent, Dept Oral Biol, 9-75 Al Octavio Pinheiro Brisolla, Bauru, SP - Brazil
[3] Univ Cruzeiro Sul, Dept Dent, 868 Galvao Bueno, Sao Paulo, SP - Brazil
[4] Aparicio Carvalho Univ Ctr, Dept Dent, 241 Araras St, Porto Velho, RO - Brazil
[5] Univ Oulu, Inst Dent, Oulu - Finland
[6] Oulu Univ Hosp, Med Res Ctr Oulu, POB 5281, FI-90014 Oulu - Finland
[7] Univ Oulu, POB 5281, FI-90014 Oulu - Finland
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | CLINICAL ORAL INVESTIGATIONS; v. 25, n. 4, p. 2183-2190, APR 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Objectives Evaluate the effect of dentifrices or gels containing MMP inhibitors on dentine loss in situ. Materials and methods Acrylic palatal appliances containing bovine dentine blocks were divided into two rows, corresponding to the groups erosion (ERO) and erosion associated with abrasion (ERO+ABR). For ERO, the appliances were immersed in a cola drink for 5 min, 4 times/day, while for ERO+ABR, the blocks were brushed for 15 sec with a dentifrice slurry after the second and third erosive challenges. Ten volunteers took part in study 1 (S1), where the dentifrices evaluated contained 1100 ppm fluoride as NaF, 0.61% green tea extract, or 0.012% chlorhexidine digluconate. Thirteen volunteers participated in study 2 (S2), in which the treatment was performed only once (1 min) with gels containing 400 mu M EGCG (EGCG400), 0.012% chlorhexidine, 1 mM FeSO4, 1.23% F (NaF), placebo, or received no treatment. Dentine loss was analyzed by profilometry (mu m). Results Regarding S1, ERO+ABR induced significantly higher dentine loss compared with ERO and all dentifrices tested led to significantly lower dentine loss when compared with placebo. For S2, regardless of the conditions or times of evaluation, gels containing EGCG, CHX, or FeSO(4)led to significantly less wear compared with the other groups. Conclusion Both dentifrices and gels containing MMP inhibitors significantly reduced dentine loss. (AU) | |
| FAPESP's process: | 07/08389-3 - Evaluation of the effect of matrix metalloproteinases inhibitors on dental erosion: in situ / ex vivo studies |
| Grantee: | Marília Afonso Rabelo Buzalaf |
| Support Opportunities: | Regular Research Grants |