Oral and oropharyngeal diffuse large B-cell lymphoma and high-grade B-cell lymphoma: A clinicopathologic and prognostic study of 69 cases

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Rodrigues-Fernandes, Carla Isabelly ^[1] ; Goncalves Junior, Arnaldo ^[2] ; Soares, Ciro Dantas ^[1] ; de Lima Morais, Thayna Melo ^[1] ; do Amaral-Silva, Gleyson Kleber ^[1] ; Freire de Carvalho, Maria Goretti ^[3] ; de Souza, Lucas Lacerda ^{[1, 2]} ; Pires, Fabio Ramoa ^[4] ; Ribeiro Bartholomeu dos Santos, Teresa Cristina ^[4] ; Pereira, Debora Lima ^[1] ; Rivero, Luis Fernando ^[5] ; Bezerra, Kelly Tambasco ^[6] ; Benevenuto de Andrade, Bruno Augusto ^[6] ; Romanach, Mario Jose ^[6] ; Agostini, Michele ^[6] ; Henao, Javier Rendon ^[7] ; Gabriel, Amanda de Farias ^[8] ; Pinto Junior, Decio dos Santos ^[9] ; Martins, Manoela Domingues ^[8] ; de Carvalho Pereira, Mateus Jose ^[10] ; Mesquita, Ricardo Alves ^[10] ; Gomez, Ricardo Santiago ^[10] ; Souto, Giovanna Ribeiro ^[11] ; Santos-Silva, Alan Roger ^[1] ; Vargas, Pablo Agustin ^{[1, 12]} ; Lopes, Marcio Ajudarte ^[1] ; de Almeida, Oslei Paes ^[1] ; Correa Pontes, Flavia Sirotheau ^[2] ; Rebelo Pontes, Helder Antonio ^[2] ; Rodriguez Burbano, Rommel Mario ^[3] ; Fonseca, Felipe Paiva ^{[1, 10, 9]}

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^[1] Univ Estadual Campinas, Dept Oral Diag, Piracicaba Dent Sch, Piracicaba - Brazil

^[2] Fed Univ Para, Joao de Barros Barreto Univ Hosp, Serv Oral Pathol, Belem, Para - Brazil

^[3] Private Pathol Serv, Natal, RN - Brazil

^[4] Univ Estado Rio De Janeiro, Dent Sch, Oral Pathol, Rio De Janeiro - Brazil

^[5] Univ Fed Rio Grande do Sul, Fac Med, Dept Pathol, Porto Alegre, RS - Brazil

^[6] Univ Fed Rio de Janeiro, Sch Dent, Dept Oral Diag & Pathol, Rio De Janeiro - Brazil

^[7] Univ Antioquia, Dept Pathol, Medellin - Colombia

^[8] Fed Univ Rio Grande, Sch Dent, Dept Pathol, Porto Alegre, RS - Brazil

^[9] Univ Sao Paulo, Dent Sch, Dept Oral Diag, Sao Paulo - Brazil

^[10] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, Av Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG - Brazil

^[11] Pontificia Univ Catolica Minas Gerais, Dept Dent, Belo Horizonte, MG - Brazil

^[12] Univ Pretoria, Dept Oral Biol & Oral Pathol, Pretoria - South Africa

• Document type: Journal article
• Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 131, n. 4, p. 452+, APR 2021.
• Web of Science Citations: 0

Abstract

oral/oropharyngeal Objective. The objective of this study was to describe the clinicopathological, molecular, and prognostic features of oral/oropharyngeal diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma. Study Design. All cases were retrieved from 7 Brazilian institutions. Immunohistochemical reactions were performed to confirm the diagnoses and to categorize the tumors. In situ hybridization was used to detect Epstein-Barr virus (EBV) and fluorescence in situ hybridization was used to identify gene rearrangements. Results. Most cases involved the oral cavity (76.8%). Males and females, with a mean age of 60 years, were evenly affected. Tumors mostly presented as painful swellings. Forty cases represented germinal center B-cell type (58%). Five cases presented double-hit translocation and 3 harbored rearrangement for MYC/BCL2/BCL6. EBV was detected in 3 cases (4.3%). The 5-year overall survival was 44.4%. Female sex, presence of pain and ulcer, microscopic ``starry sky pattern{''} and necrosis, co-expression of c-Myc/Bcl2, and translocation of MYC were associated with a lower survival in univariate analysis (P =.05, P =.01, P =.01, P =.03, P =.05, P =.006, P =.05, respectively). Conclusion. Patients affected by oral/oropharyngeal DLBCL have a low survival rate. High-grade B-cell lymphoma (17.7%) and EBV-positive DLBCL, not otherwise specified (4.3%) account for a small number of cases. (AU)

• FAPESP's process: 17/14880-3 - Clinicopathological and immunohistochemical analysis of follicular lymphoid hyperplasias and lymphomas of the oral cavity
• Grantee: Oslei Paes de Almeida
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/08995-2 - Epigenetic events in ameloblastomas: immuno-expression of DNMT1, DNMT3b and H3K9ac and hMutS promoters' methylation profile
• Grantee: Gleyson Kleber do Amaral Silva
• Support Opportunities: Scholarships in Brazil - Doctorate