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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Performance of functionality measures and phase angle in women exposed to chemotherapy for early breast cancer

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Author(s):
da Silva, Bruna Ramos [1] ; Mialich, Mirele S. [1] ; Cruz, Loris P. [2] ; Rufato, Sarah [1] ; Gozzo, Thais [2] ; Jordao, Alceu A. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Hlth Sci, Bandeirantes Ave 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Nursing Sch Ribeirao Preto, Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CLINICAL NUTRITION ESPEN; v. 42, p. 105-116, APR 2021.
Web of Science Citations: 0
Abstract

Purpose: The study aimed to analyze the influence of chemotherapy on nutritional status and the phase angle (PhA) as nutritional indicator for breast cancer women undergoing chemotherapy. Methods: A prospective study was performed. Women who were starting chemotherapy with no previous chemotherapy treatment were recruited. Quality of life (QoL) was collected using the EORTC QLQBR23 questionnaire. Bioelectrical impedance analysis, performance tests, and blood sample to albumin analyzes were collected at 2-time points: diagnosis (T0) and after 1 month of completion of therapy (T1). Mean, standard deviation, linear regression, and ANOVA in R were used to explore the results. Results: 61 women were included. We did not find any changes in body composition. However, PhA, nutritional risk index (NRI), gait speed (GS), and handgrip strength (HGS) had expressive changes (p < 0.001). 75.4% of women had PhA values below the cut-off point of 5.6 degrees, and the group that had a lower average of PhA also expressed low NRI. PhA was a nutritional status marker and its values were influenced by changes in NRI (p < 0.05). Conclusion: We have found supporting evidence for chemotherapy treatment resulting in worsening of prognostic factors such as PhA, and yet PhA was related to no nutritional risk. Besides a higher prevalence of obesity, 80% of the sample showed some nutritional risk level, implying the possibility of a subnotification candidate who might benefit, for instance, from nutritional intervention in obesity groups. Further investigation about this theme may improve health measures for the prevention and screening of disease among breast cancer. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights (AU)

FAPESP's process: 17/07963-0 - Evaluation of the metabolic, oxidative and anthropometric profile in women with Breast Cancer
Grantee:Bruna Ramos da Silva
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)