| Full text | |
| Author(s): |
Dias Junior, Elcio Malcher
[1]
;
Costa Dias, Dayane dos Reis
[1]
;
Drummond Rodrigues, Ana Paula
[2]
;
Barroso Tavares Dias, Carmen Gilda
[3]
;
Tavares Bastos, Gilmara de Nazareth
[1]
;
Rocha de Oliveira, Johnatt Allan
[4]
;
Maciel Filho, Rubens
[5]
;
Passos, Marcele Fonseca
[1, 5]
Total Authors: 8
|
| Affiliation: | [1] Fed Univ Para, Inst Biol Sci, BR-66075110 Belem, Para - Brazil
[2] Evandro Chagas Inst, Microscopy Lab, BR-66090110 Belem, Para - Brazil
[3] Fed Univ Para, Dept Mech Engn, BR-66075110 Belem, Para - Brazil
[4] Fed Univ Para, Dept Nutr, BR-66075110 Belem, Para - Brazil
[5] Univ Estadual Campinas, Natl Inst Sci & Technol Biofabricat BIOFABRIS, Chem Engn Dept, BR-13083852 Campinas, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | MATERIALS TODAY COMMUNICATIONS; v. 26, MAR 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Despite the many advances in the field of regenerative medicine, the use of biomaterials to repair the cartilaginous tissue's traumatic injuries is still a challenge. Based on that, this research focuses on the semi-interpenetrating polymeric scaffolds (SIPNs) based PLLA and PHEMA. The material was produced in the solvent absence as a strategy to outline the critical limitations of hydrophilicity and the lack of biological interaction of biomaterials with the surrounding tissues. To this end, the thermal properties and chemical structure were characterized using thermogravimetric analysis and spectroscopy in the Fourier transform infrared. Besides, we assessed porosity and tissue interactions by scanning electron microscopy, and the influence of this in the swelling capacity tests. In vitro and in vivo assays and histological analysis were developed to assess the biocompatibility of SIPNs scaffolds. The results showed good thermal stability, porosity in the range of 53.73 to 94.34 mu m, absence of toxicity, and excellent in vitro cell adhesion and growth. The biomaterial also promoted a great template for cell migration and spreading in vivo, with high cartilaginous tissue remodeling. SIPNs scaffolds demonstrated its biocompatibility and potential use in tissue engineering. (AU) | |
| FAPESP's process: | 11/18525-7 - IPNs networks of pHEMA-PLA for use in Tissue Engineering |
| Grantee: | Marcele Fonseca Passos |
| Support Opportunities: | Scholarships in Brazil - Doctorate |