A Systematic Review of MicroRNAs Involved in Cervical Cancer Progression

Author(s)

Causin, Rhafaela Lima ^[1] ; Freitas, Ana Julia Aguiar de ^[1] ; Trovo Hidalgo Filho, Cassio Murilo ^[2] ; Reis, Ricardo dos ^[3] ; Reis, Rui Manuel ^{[1, 4, 5]} ; Marques, Marcia Maria Chiquitelli ^{[6, 1]}

Affiliation

^[1] Barretos Canc Hosp, Teaching & Res Inst, Mol Oncol Res Ctr, BR-14784400 Barretos, SP - Brazil

^[2] Inst Canc Estado Sao Paulo ICESP, BR-01246000 Sao Paulo, SP - Brazil

^[3] Barretos Canc Hosp, Gynecol Oncol Dept, BR-14784400 Sao Paulo - Brazil

^[4] Univ Minho, Med Sch, Life & Hlth Sci Res Inst ICVS, P-4704553 Braga - Portugal

^[5] ICVS 3BsPT Govt Associate Lab, P-4806909 Braga - Portugal

^[6] Dr Paulo Prata FACISB, Barretos Sch Hlth Sci, BR-14785002 Sao Paulo - Brazil

• Document type: Review article
• Source: CELLS; v. 10, n. 3 MAR 2021.
• Web of Science Citations: 0

Abstract

To obtain a better understanding on the role of microRNAs in the progression of cervical cancer, a systematic review was performed to analyze cervical cancer microRNA studies. We provide an overview of the studies investigating microRNA expression in relation to cervical cancer (CC) progression, highlighting their common outcomes and target gene interactions according to the regulatory pathways. To achieve this, we systematically searched through PubMed MEDLINE, EMBASE, and Google Scholar for all articles between April 2010 and April 2020, in accordance with the PICO acronym (participants, interventions, comparisons, outcomes). From 27 published reports, totaling 1721 cases and 1361 noncancerous control tissue samples, 26 differentially expressed microRNAs (DEmiRNAs) were identified in different International Federation of Gynecology and Obstetrics (FIGO) stages of cervical cancer development. It was identified that some of the dysregulated microRNAs were associated with specific stages of cervical cancer development. The results indicated that DEmiRNAs in different stages of cervical cancer were functionally involved in several key hallmarks of cancer, such as evading growth suppressors, enabling replicative immortality, activation of invasion and metastasis, resisting cell death, and sustained proliferative signaling. These dysregulated microRNAs could play an important role in cervical cancer's development. Some of the stage-specific microRNAs can also be used as biomarkers for cancer classification and monitoring the progression of cervical cancer. (AU)

• FAPESP's process: 16/15831-3 - Molecular signatures of microRNAs in precursor lesions of cervical cancer
• Grantee: Rhafaela Lima Causin
• Support Opportunities: Scholarships in Brazil - Master