| Full text | |
| Author(s): Show less - |
Sichero, Laura
[1]
;
Ferreira, Silvaneide
[1]
;
Lopez, Rossana V. M.
[1]
;
Mello, Barbara P.
[1]
;
Costa, Victor
[2]
;
El-Achkar, Vivian N. R.
[2]
;
Carlos, Roman
[3]
;
Ribeiro-Silva, Alfredo
[4]
;
Pignatari, Shirley
[5]
;
Kaminagakura, Estela
[2]
;
Villa, Luisa L.
[6, 5, 1]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Ctr Translat Res Oncol, Inst Canc Estado Sao Paulo, Hosp Clin, Fac Med, Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Dept Bioscience & Oral Diag, Sao Paulo - Brazil
[3] Ctr Clin Cabeza & Cuello, Guatemala City - Guatemala
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol & Forens Med, Ribeirao Preto - Brazil
[5] Sao Paulo Fed Univ, Dept Otorhinolaryngol & Head & Neck Surg, Sao Paulo - Brazil
[6] Univ Sao Paulo, Dept Radiol & Oncol, Fac Med, Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Journal of Medical Virology; v. 93, n. 6, p. 3835-3840, JUN 2021. |
| Web of Science Citations: | 1 |
| Abstract | |
Human papillomavirus (HPV) types 6 and 11 are the etiological agents of recurrent respiratory papillomatosis (RRP). We examined the prevalence and distribution of HPVs 6 and 11 genetic variants in juvenile onset (JORRP) and adult onset (AORRP) laryngeal papillomas. Cases of JORRP and AORRP were collected, retrospectively. HPV detection and genotyping were accessed by polymerase chain reaction-sequencing in 67 RRP samples. Overall, the most prevalent HPV-6 variants were from B1 (55.8%) and B3 (27.9%) sublineages, whereas among HPV-11 positive samples A2 (62.5%) variants were predominant. A higher prevalence of HPV-6 B1 was observed in JORRP (83.3% B1 and 16.7% B3), compared with AORRP cases (58.3% B1 and 41.7% B3). HPV-11 A2 variants were more prevalent both in JORRP (57.2%) and in AORRP cases (70.0%). Nevertheless, with the exception that HPV-6 B1 were significantly less likely to recur, there was a lack of association between any particular HPVs 6 or 11 variant and clinicopathological features. Our data do not support an association between HPVs 6 and 11 variability and RRP. (AU) | |
| FAPESP's process: | 17/23211-8 - Impact of genetic variants of HPV on persistence of infection and risk of disease: an epidemiological and functional approach |
| Grantee: | Laura Cristina Sichero Vettorazzo |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/24019-0 - INVESTIGATION OF THE PRESENCE OF EPSTEIN-BARR VIRUS AND ITS POSSIBLE CONTRIBUTION TO LARYNGEAL PAPILLOMATOSIS AGGRESSIVENESS AND MALIGNIZATION |
| Grantee: | Estela Kaminagakura Tango |
| Support Opportunities: | Regular Research Grants |