Recent Advances in Molecular Hydrogen Research Reducing Exercise-Induced Oxidative Stress and Inflammation

Author(s)

Nogueira, Jonatas E. ^[1] ; Branco, Luiz G. S. ^[2]

Affiliation

^[1] Univ Sao Paulo, Sch Phys Educ & Sports Ribeirao Preto, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dent Sch Ribeirao Preto, Dept Basic & Oral Biol, BR-14040904 Ribeirao Preto, SP - Brazil

• Document type: Review article
• Source: CURRENT PHARMACEUTICAL DESIGN; v. 27, n. 5, p. 731-736, 2021.
• Web of Science Citations: 1

Abstract

Physical exercise-induced oxidative stress and inflammation may be beneficial when exercise is a regular activity, but it is rather harmful when exercise is exhaustive and performed by unaccustomed organisms. Molecular hydrogen (H-2) has recently appeared as a potent antioxidant and anti-inflammatory molecule in numerous pathological conditions. However, its role is relatively unknown under physiological conditions such as physical exercise. Therefore, this review summarizes the current knowledge of the H-2, reducing oxidative stress and inflammation in physical exercise, reporting data from both animal and human studies. (AU)

• FAPESP's process: 16/17681-9 - Pathophysiological changes during systemic inflammation
• Grantee: Luiz Guilherme de Siqueira Branco
• Support Opportunities: Research Projects - Thematic Grants