| Full text | |
| Author(s): |
Uchiyama, Mayara K.
[1]
;
Hebeda, Cristina B.
[2]
;
Sandri, Silvana
[2]
;
Paula-Silva, Marina de
[2]
;
Romano, Mariana
[1]
;
Cardoso, Roberta M.
[1]
;
Toma, Sergio H.
[1]
;
Araki, Koiti
[1]
;
Farsky, Sandra H. P.
[2]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Lab Supramol Chem & Nanotechnol, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, Lab Expt Toxicol, Ave Prof Lineu Prestes 580, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Nanomedicine; v. 16, n. 9 APR 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Aim: The low solubility and consequent poor bioavailability of ibuprofen (IBU) is a major drawback that can be overcome by anchoring IBU on ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) as effective multifunctional carriers for drug delivery. Methods: USPIONs were conjugated with glycerol phosphate (USPION-GP) and also co-conjugated with IBU (USPION-GP/IBU), and their in vivo toxicity and anti-inflammatory effects investigated. Phosphate buffer saline (Control), IBU, USPION-GP and USPION-GP/IBU were intravenously administered 15 min before lipopolysaccharide-induced peritonitis in male Balb/c mice. Results: 4 h later, USPION bioconjugates did not appear to have caused toxicity to blood leukocytes or caused alterations in the spleen, liver or kidneys. Also, they inhibited lipopolysaccharide-induced neutrophil mobilization into the peritoneum. Conclusion: The absence of systemic toxicity and the unexpected anti-inflammatory action of USPION bioconjugates indicates that they could be a novel and effective approach to administer IBU and warrant further investigation. (AU) | |
| FAPESP's process: | 18/21489-1 - Supramolecular nanotechnology: design, materials and devices |
| Grantee: | Henrique Eisi Toma |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/07328-4 - Identification of endogenous pathways for the control of inflammation |
| Grantee: | Sandra Helena Poliselli Farsky |
| Support Opportunities: | Research Projects - Thematic Grants |