| Full text | |
| Author(s): |
Total Authors: 3
|
| Affiliation: | [1] Univ Sao Paulo, Dept Immunol, Lab Immunobiol Transplantat, Sao Paulo - Brazil
[2] Univ Fed ABC, Ctr Nat & Human Sci, Santo Andre, SP - Brazil
[3] Univ Fed Sao Paulo, Div Nephrol, Lab Clin & Expt Immunol, Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | NATURE REVIEWS NEPHROLOGY; v. 17, n. 7 APR 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Immune cells have important roles in many kidney diseases and their phenotypes are intricately connected to their metabolic profiles. Here, the authors explore the metabolic programs of different kidney immune cells and their phenotypes, and the potential of targeting immunometabolism in the kidney. Insights into the relationship between immunometabolism and inflammation have enabled the targeting of several immunity-mediated inflammatory processes that underlie infectious diseases and cancer or drive transplant rejection, but this field remains largely unexplored in kidney diseases. The kidneys comprise heterogeneous cell populations, contain distinct microenvironments such as areas of hypoxia and hypersalinity, and are responsible for a functional triad of filtration, reabsorption and secretion. These distinctive features create myriad potential metabolic therapeutic targets in the kidney. Immune cells have crucial roles in the maintenance of kidney homeostasis and in the response to kidney injury, and their function is intricately connected to their metabolic properties. Changes in nutrient availability and biomolecules, such as cytokines, growth factors and hormones, initiate cellular signalling events that involve energy-sensing molecules and other metabolism-related proteins to coordinate immune cell differentiation, activation and function. Disruption of homeostasis promptly triggers the metabolic reorganization of kidney immune and non-immune cells, which can promote inflammation and tissue damage. The metabolic differences between kidney and immune cells offer an opportunity to specifically target immunometabolism in the kidney. (AU) | |
| FAPESP's process: | 15/26682-6 - Evaluation of mTOR on energy metabolism and activation of B cells during experimental intestinal inflammation |
| Grantee: | Paulo José Basso |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 19/14755-0 - Shaping gut microbiota and immune system by the intestinal epithelial cells: from tissue homeostasis to diseases |
| Grantee: | Vinicius de Andrade Oliveira |
| Support Opportunities: | Research Grants - Young Investigators Grants |